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Multi-Functional Nanomaterial Based Nanosensors

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2784

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Guest Editor
Research Institute for Biomolecular Chemistry, Dongguk University, Seoul 04620, Republic of Korea
Interests: hybrid nanomaterials; multi-functional nanostructures; biosensors; drug delivery systems; self-assembly; materials chemistry; nanochemistry
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Special Issue Information

Dear Colleagues,

In recent years, the development of highly sensitive and selective sensing platforms has been a focus of research, with the aim of improving public health and people’s well-being. In order to meet such aims, many researchers have introduced several multi-functional nanomaterials, which have high electrical conductivity; plasmonic, catalytic, magnetic and optical properties; and can be used to investigate high-performance sensing systems.

A multi-functional nanomaterial can play a role as a sensing channel that can directly or indirectly interact with a target material, including biomaterials, gas molecules, etc. Additionally, the sensing performance is determined by monitoring the change in its properties after interaction. Furthermore, the synergic effects of nanomaterials could improve sensing performance. Thus, to obtain high-performance sensing systems with excellent sensitivity, selectivity and reproducibility, functionalized nanomaterials are essential, with such nanomaterial-based nanosensors being able to contribute toward a better quality of life.

Dr. Jaewook Lee
Guest Editor

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Published Papers (1 paper)

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Research

12 pages, 4273 KiB  
Article
Magnetofluoro-Immunosensing Platform Based on Binary Nanoparticle-Decorated Graphene for Detection of Cancer Cell-Derived Exosomes
by Jaewook Lee, Ji-Heon Lee, Jagannath Mondal, Joon Hwang, Han Sang Kim, Vinoth Kumar, Akhil Raj, Seung Rim Hwang and Yong-Kyu Lee
Int. J. Mol. Sci. 2022, 23(17), 9619; https://doi.org/10.3390/ijms23179619 - 25 Aug 2022
Cited by 6 | Viewed by 2323
Abstract
Multi-functionalized carbon nanomaterials have attracted interest owing to their excellent synergic properties, such as plasmon resonance energy transfer and surface-enhanced Raman scattering. Particularly, nanoparticle (NP)-decorated graphene (GRP) has been applied in various fields. In this study, silver NP (AgNP)- and magnetic iron oxide [...] Read more.
Multi-functionalized carbon nanomaterials have attracted interest owing to their excellent synergic properties, such as plasmon resonance energy transfer and surface-enhanced Raman scattering. Particularly, nanoparticle (NP)-decorated graphene (GRP) has been applied in various fields. In this study, silver NP (AgNP)- and magnetic iron oxide NP (IONP)-decorated GRP were prepared and utilized as biosensing platforms. In this case, AgNPs and GRP exhibit plasmonic properties, whereas IONPs exhibit magnetic properties; therefore, this hybrid nanomaterial could function as a magnetoplasmonic substrate for the magnetofluoro-immunosensing (MFI) system. Conversely, exosomes were recently considered high-potential biomarkers for the diagnosis of diseases. However, exosome diagnostic use requires complex isolation and purification methods. Nevertheless, we successfully detected a prostate-cancer-cell-derived exosome (PC-exosome) from non-purified exosomes in a culture media sample using Ag/IO-GRP and dye-tetraspanin antibodies (Ab). First, the anti-prostate-specific antigen was immobilized on the Ag/IO-GRP and it could isolate the PC-exosome from the sample via an external magnetic force. Dye-tetraspanin Ab was added to the sample to induce the sandwich structure. Based on the number of exosomes, the fluorescence intensity from the dye varied and the system exhibited highly sensitive and selective performance. Consequently, these hybrid materials exhibited excellent potential for biosensing platforms. Full article
(This article belongs to the Special Issue Multi-Functional Nanomaterial Based Nanosensors)
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