Molecular Risk Stratification in Sarcomas: Epigenomics in Osteosarcomas
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 27
Special Issue Editor
Special Issue Information
Dear Colleagues,
Sarcomas are malignant neoplasms derived from mesenchymal tissue, accounting for only 1% of all malignant tumors globally. With around 200 subtypes, sarcomas vary in treatment and prognosis, with surgery being the primary treatment. In certain subtypes, postoperative chemotherapy or chemo-radiotherapy is used, which can be aggressive and highly mutilating. Oncogenic pathways allow classification into two main subgroups: homogeneous morphology sarcomas, often involving balanced gene alterations, and high-grade sarcomas with complex chromosomal changes such as ring chromosomes and chromothripsis.
Unfortunately, there are few molecular targets for specific treatment, such as C-KIT in Gastrointestinal Stromal Tumors (GISTs) or N-TRK in sarcomas with relevant gene alterations.
Optical genome mapping is currently being used to identify structural DNA alterations, and advances in epigenomics offer valuable insights into tumor biology. Epigenomics could particularly improve risk stratification in osteosarcomas by identifying epigenetic changes that affect tumor behavior and treatment response. Together, these technologies could help predict tumor evolution, identify new molecular targets, and develop more effective, targeted therapies for sarcoma patients.
Dr. Empar Mayordomo-Aranda
Guest Editor
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Keywords
- sarcomas
- malignant neoplasms
- oncogenic pathways
- optical genome mapping
- epigenomics
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