Role of Redox Homeostasis and Oxidative Stress in Human Health 2.0

Dear Colleagues,

Redox homeostasis plays an important role in the physiological processes and pathogenesis of various diseases. There have been recent advances in the field of redox biology and medicine. A number of chemical species, such as hydrogen sulfide and carbon monoxide, emerged as regulators of redox homeostasis. The involvement of these molecules in physiological regulation awaits further investigation. Redox signaling is implicated in regulatory mechanisms. Reactive oxygen species may oxidize the critical residues (such as cysteine, methionine, etc.) of regulatory proteins and alter their functions. The application of proteomics to study the oxidative post-translational modification (PTM) of proteins and of metabolomics to study the effect of the interactions between redox regulation and metabolic reprogramming opens an avenue to investigate redox biology in a system biology-based manner. Moreover, endogenous antioxidants are key players in physiological and pathophysiological processes. For instance, thioredoxin has been implicated in the chemoresistance of tumor cells. Proper management of the antioxidative systems may prove invaluable to the therapy of diseases. The development of novel synthetic antioxidants and/or mitochondrion-specific antioxidants can serve such a purpose. For example, mitochondrion-targeted antioxidants improve the insulin sensitivity of skeletal muscles and age-related functional deterioration. The isolation and study of natural compounds with antioxidant activity contributes to the development of therapeutic interventions for various diseases. Infectious diseases are amenable to such treatments. Recent studies also point to an involvement of redox homeostasis in the modulation of immunity and in the pathogenesis of microbial and viral diseases. This issue is particularly important as we are still in the midst of the COVID-19 pandemics.

The editor of this Special Issue invites researchers in the field of redox biology to submit original research articles and review articles on these topics.

Prof. Dr. Hung-Yao Ho
Guest Editor

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• reactive oxygen species
• antioxidants
• aging
• immunity
• metabolism
• metabolomics
• metabolic syndromes
• degenerative diseases
• cardiovascular diseases
• infectious diseases
• oxidative post-translational modifications
• redoxomics

• Role of Redox Homeostasis and Oxidative Stress in Human Health in International Journal of Molecular Sciences (9 articles)