Skin Histopathology: Focused on Ageing and Cancer

Dear Colleagues,

Skin represents the largest organ of the human body with numerous physiological functions. Notably, the skin as a barrier is life-long exposed to the outer environment, and it is facing all its potentially damaging effects. Therefore human skin suffers from both either intrinsic ageing, but also extrinsic factors enhancing this process.

Ageing is accompanied by a plethora of phenotypic changes in the structure of cutaneous cells and extracellular matrix, but also by their functional changes.  As a result, aged skin is associated with higher susceptibility to poor self-renewal and healing, with increased risk of development of various dermatoses, and it is also prone to develop skin cancer.

In this Special Issue, we wish to broaden our understanding to skin ageing, highlight recent hot topics in structural and functional changes of skin and also unveil molecular mechanisms leading to these changes.

We aim to promote knowledge and understanding of the various facets related to skin health and disease with emphasis on various aspects of cutaneous ageing-related pathologies because it can strengthen our diagnostic and treatment strategies and potentially prevent or even reverse skin ageing.

Dr. Lukas Lacina
Dr. Michal Kolář
Guest Editors

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