Regulatory T Cells in Human Disease and in Transplantation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (30 May 2023) | Viewed by 4152
Special Issue Editors
Interests: T regulatory cells; autoimmunity; transplantation; Tregs
Interests: immune regulation; allergy; asthma; T cell responses; cytokines; regulatory T cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is common knowledge that maintaining homeostasis and regulating the complex and sophisticated processes that comprise our immune system is of extreme importance so as to avoid an excessive immune reaction with fatal consequences for our body but also a reaction against self-antigens.
In the core of this refrain lay T regulatory cells (Tregs). Even though over the years there has been a debate regarding Treg identification markers, we are well aware that they are implicated in the prevention of autoimmunity, induction of peripheral tolerance, suppression of chronic inflammatory diseases and allergies .All the above are mediated through different mechanisms either direct or indirect leading to the suppression of the targeted cells (even though the identity of the latter may not always be clear).
Different Treg abnormalities either qualitative and/or quantitative have been described in a number of diseases (regardless of their autoimmune background) and infections and in some cases they seem to have a predictive value.
Given their immunomodulatory effect it was only natural for the scientific community to explore a possible use for Tregs as cellular therapies in clinical practice not only for the treatment of auto-immune disorders but also in the transplant setting where chronic rejection (in the case of solid organ transplantation) and GvHD (in the case of hematopoietic stem cell transplantation) are still challenging.
For the Special Issue “T regulatory Cell in human disease and transplantation”, we welcome your contributions in the form of original research and review articles on biomolecular or combined biomolecular and clinical aspects of Tregs aiming to bridge the remaining gaps in our knowledge regarding their biology, mechanisms of actions and their implication in different diseases and in transplantation.
Dr. Aliki Xochelli
Dr. Georgina Xanthou
Guest Editors
Manuscript Submission Information
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Keywords
- T regulatory cells
- autoimmunity
- transplantation
- Tregs
