Targeting PI3K/mTOR Signaling in Cancers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 4021
Special Issue Editor
Interests: global cancer research; colorectal cancer; pancreatic cancer; cancer biology; cancer metastasis; cancer biomarkers; molecular biology; cell survival; apoptosis; signaling pathways; medical education; acute lung disease; ARDS
Special Issue Information
Dear Colleagues,
The phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling cascade is a key regulator of cell growth, survival, metabolism, cell cycle progression, cell motility, and angiogenesis in physiological as well as pathological conditions such as cancer. The PI3K/mTOR signaling pathway is aberrantly activated in many cancers due to activation by the receptor tyrosine kinases and somatic mutations in specific components of the signaling pathway. This aberrant activation is critical in driving tumor initiation, progression, and metastasis, and is one of the main mechanisms of resistance to cancer therapy. The complex nature of the PI3K/mTOR pathway, attributed to multiple levels of feedback and crosstalk with other pathways, could contribute to the difficulty in targeting this pathway in cancers. Therefore, the identification of novel molecules at different levels of the PI3K/mTOR pathway is crucial for understanding the precise mechanism of this pathway and its inhibition.
The goal of this Special Issue is to summarize and enlarge the current knowledge on the molecular aspects of PI3K/mTOR signaling in cancer. Authors are welcome to submit original basic and translational research and review articles.
Dr. Premila Leiphrakpam
Guest Editor
Manuscript Submission Information
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Keywords
- cell survival
- apoptosis
- cell proliferation
- cell cycle regulation
- metabolism
- cytoskeleton rearrangement
- angiogenesis
- epithelial-to-mesenchymal transition
- signaling pathway aberrations
- signaling crosstalk
- tumorigenesis
- tumor cell migration
- metastasis
- novel markers
- anti-cancer agents
