Protein Disorder and Phase Separation in Transcription
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 7784
Special Issue Editors
Interests: bHLH transcription factors; protein localization; protein-protein interaction; protein structure; intrinsically disordered proteins; liquid-liquid phase separation; signal transduction
Special Issues, Collections and Topics in MDPI journals
Interests: structure-function relationship in proteins; transcription factors; intrinsically disordered proteins; membraneless organelles; liquid-liquid phase separation; biomineralization
Special Issue Information
Dear Colleagues,
Transcription underlies the development and physiology of all living organisms. This process requires tight regulation, as any of its dysregulation can lead to pathophysiology and serious disorders. Knowledge regarding the mechanism of transcription molecular details is advanced, however some important issues remain unexplored. Recent findings indicate the significance of spontaneous thermodynamically driven liquid–liquid phase separation (LLPS), leading to the formation of dense, liquid condensates. It has been proposed that transcriptional control may be linked to LLPS, and that intrinsically disordered regions of transcription factors mediating phase separation with coactivators are responsible for the regulation of the transcription level.
The Special Issue, “Protein Disorder and Phase Separation in Transcription”, aims to summarize all aspects of current knowledge concerning the role of intrinsically disordered proteins/regions and LLPS in the regulation of transcription processes. This Issue will cover a selection of original and review articles regarding recent studies focused on the role of IDP/IDR in LLPS-controlled transcription processes, as well as in the context of pathophysiology, leading to different kind of disorders. Experimental and theoretical papers, up-to-date review articles, and commentaries are welcome.
Dr. Beata Greb-Markiewicz
Prof. Dr. Andrzej Ożyhar
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Transcription factors
- Transcriptional regulation
- Mediator complex
- Protein–protein interaction
- Intrinsically disordered protein
- Intrinsically disordered region
- Liquid–liquid phase separation
- Phase transition
- Post-transcriptional modification
- Membraneless organelles
- Molecular crowding
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.