Protein Disorder and Phase Separation in Transcription

Dear Colleagues,

Transcription underlies the development and physiology of all living organisms. This process requires tight regulation, as any of its dysregulation can lead to pathophysiology and serious disorders. Knowledge regarding the mechanism of transcription molecular details is advanced, however some important issues remain unexplored. Recent findings indicate the significance of spontaneous thermodynamically driven liquid–liquid phase separation (LLPS), leading to the formation of dense, liquid condensates. It has been proposed that transcriptional control may be linked to LLPS, and that intrinsically disordered regions of transcription factors mediating phase separation with coactivators are responsible for the regulation of the transcription level.

The Special Issue, “Protein Disorder and Phase Separation in Transcription”, aims to summarize all aspects of current knowledge concerning the role of intrinsically disordered proteins/regions and LLPS in the regulation of transcription processes. This Issue will cover a selection of original and review articles regarding recent studies focused on the role of IDP/IDR in LLPS-controlled transcription processes, as well as in the context of pathophysiology, leading to different kind of disorders. Experimental and theoretical papers, up-to-date review articles, and commentaries are welcome.

Dr. Beata Greb-Markiewicz
Prof. Dr. Andrzej Ożyhar
Guest Editors

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