Platelet Activation and Prothrombotic Factors for Atherosclerosis

Dear Colleagues,

Proinflammatory and prothrombotic factors can induce endothelial dysfunction and atherosclerotic plaque formation and progression. The activation of platelets induces an increase in proinflammatory and prothrombotic factors, by contact with monocytes/macrophages and neutrophils. Platelet–leukocyte crosstalk regulates leukocyte recruitment, the proliferation and differentiation of leukocytes, and the production of proinflammatory factors such as cytokines. The crosstalk between platelets and leukocytes may play a crucial role in atherogenesis; however, the underlying mechanisms remain unknown. This Special Issue will feature the contributions of platelet activation/prothrombotic factors showing platelet–leukocyte crosstalk to atherosclerosis.

It is currently very difficult to prove platelet activation. Focusing on the fact that activated platelets release serotonin, we have developed a highly accurate serotonin measurement system. Using the system, we found a significant association between plasma serotonin levels and atherosclerotic progression in type 2 diabetic patients. We would like to introduce our exciting results. We also welcome the submission of original articles, review articles, communications and letters on platelet–leukocyte crosstalk. I would like to make the Special Issue “Platelet Activation and Prothrombotic Factors for Atherosclerosis” great with your enormous help.

Prof. Yuji Hirowatari
Guest Editor

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