Protease-Activated Receptor 1 in Human Carotid Atheroma Is Significantly Related to Iron Metabolism, Plaque Vulnerability, and the Patient’s Age
Abstract
:1. Introduction
2. Results
2.1. PAR1 Expression Is Significantly Increased with the Progression of Human Atherosclerotic Plaques and Patient’s Age
2.2. PAR1 Expression Is Significantly Correlated with Accumulation of CD68-Positive Macrophages, Ferritin, and TfR1, and Inversely Correlated with Levels of HDL
2.3. PAR1 Is Significantly Increased in Macrophages Exposed to Iron and Colocalized with Ferritin Expression
3. Discussion
Limitation
4. Materials and Methods
4.1. Collection of Carotid Artery Samples
4.2. Immunohistochemistry
4.3. Classification of the Plaques
4.4. Cell Cultures and Experimental Conditions
4.5. Double Immunocytochemistry
4.6. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Li, W.; Osman, E.; Forssell, C.; Yuan, X.-M. Protease-Activated Receptor 1 in Human Carotid Atheroma Is Significantly Related to Iron Metabolism, Plaque Vulnerability, and the Patient’s Age. Int. J. Mol. Sci. 2022, 23, 6363. https://doi.org/10.3390/ijms23126363
Li W, Osman E, Forssell C, Yuan X-M. Protease-Activated Receptor 1 in Human Carotid Atheroma Is Significantly Related to Iron Metabolism, Plaque Vulnerability, and the Patient’s Age. International Journal of Molecular Sciences. 2022; 23(12):6363. https://doi.org/10.3390/ijms23126363
Chicago/Turabian StyleLi, Wei, Ehab Osman, Claes Forssell, and Xi-Ming Yuan. 2022. "Protease-Activated Receptor 1 in Human Carotid Atheroma Is Significantly Related to Iron Metabolism, Plaque Vulnerability, and the Patient’s Age" International Journal of Molecular Sciences 23, no. 12: 6363. https://doi.org/10.3390/ijms23126363