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New Diagnostic Tools and Biomarkers in Oncological Diseases 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 1027

Special Issue Editor


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Guest Editor
Department of Life Sciences, University of Trieste, Giorgeri 1, 34127 Trieste, Italy
Interests: biological fluids; cancer; cancer biomarkers; cfDI; cfDNA; cfNA; copy number variation; ctDNA; ddPCR; disease-free survival; epigenetic; epigenetic sequencing; exosome; extracellular vesicle; genotyping; liquid biopsy; miRNA; mRNA; mutation; ncRNA; next- generation sequencing; overall survival; progression-free survival; recurrence-free survival; whole-exome sequencing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Personalized medicine has become a new paradigm for the treatment of a variety of diseases.

New diagnostic tools and biomarkers have transformed the understanding of oncologic diseases over the past decade and have helped to provide patients with the best screening, diagnosis, prognosis, therapy, and follow-up.

For example, liquid biopsy has great potential for precision medicine, especially in solid tumors, liquid biopsy is suitable for screening, diagnosis, prognosis, predictive value, and disease monitoring. In addition, other small molecules such as miRNA, ncRNA, and exosomes can be used for tumor diagnosis, prognosis, and therapy. Also, the new technologies and the high throughput facilities have substantially increased the sensitivity and rapidity of the oncological tests and other potential improvements are ongoing.

This Special Issue aims to publish the recent advances in the new diagnostic tools and biomarkers for oncological diseases. Original research and review articles are welcome in this Special Issue.

More published papers can be found in the closed special issue: New Diagnostic Tools and Biomarkers in Oncological Diseases.

Dr. Bruna Scaggiante
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oncologic diseases
  • biomarkers
  • liquid biopsy
  • miRNA
  • ncRNA
  • exosomes

Published Papers (1 paper)

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Research

13 pages, 3658 KiB  
Article
Identification of Serum Biomarkers to Monitor Therapeutic Response in Intestinal-Type Gastric Cancer
by Laura F. Dagley, Jumana Yousef, Adele Preaudet, Andrea Loving, Andrew I. Webb, Matthias Ernst and Tracy L. Putoczki
Int. J. Mol. Sci. 2024, 25(6), 3129; https://doi.org/10.3390/ijms25063129 - 08 Mar 2024
Viewed by 616
Abstract
There are a limited number of clinically useful serum biomarkers to predict tumor onset or treatment response in gastric cancer (GC). For this reason, we explored the serum proteome of the gp130Y757F murine model of intestinal-type gastric cancer (IGC). We identified 30 [...] Read more.
There are a limited number of clinically useful serum biomarkers to predict tumor onset or treatment response in gastric cancer (GC). For this reason, we explored the serum proteome of the gp130Y757F murine model of intestinal-type gastric cancer (IGC). We identified 30 proteins with significantly elevated expression in early gp130Y757F IGC and 12 proteins that were significantly elevated in late gp130Y757F IGC compared to age- and gender-matched wild-type mice. Within these signatures, there was an overlap of 10 proteins commonly elevated in both early- and late-stage disease. These results highlight the potential to identify serum biomarkers of disease stage. Since IGC in the gp130Y757F model can be reversed following therapeutic inhibition of Interleukin (IL)-11, we explored whether the protein signatures we identified could be used to monitor tumor regression. We compared two different therapeutic modalities and found 5 proteins to be uniquely differentially expressed between control animals and animals halfway through treatment, with 10 differentially expressed at the end of treatment. Our findings highlight the potential to identify reliable biomarkers to track IGC tumor regression in response to treatment. Full article
(This article belongs to the Special Issue New Diagnostic Tools and Biomarkers in Oncological Diseases 2.0)
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