Glutamatergic Signaling in the Nervous System
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 1141
Special Issue Editors
2. Department of Neuroscience, Mayo Clinic Graduate School of Biomedical Sciences, CRB, 03-031E, Scottsdale, AZ 85259, USA
Interests: brain imaging; substance use disorder; novel therapeutics; glutamatergic signaling; deep brain stimulation
Interests: retina; ribbon synapses; synaptic ribbon; active zone; synaptic signaling in photoreceptor ribbon synapses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The discovery of glutamate as a major excitatory neurotransmitter has sparked interest in understanding its role in physiological brain processes and how glutamatergic alterations can lead to various neurological and psychiatric disorders. The brain’s glutamate concentration is tightly regulated at every step, from neuronal synthesis to storage into vesicles, release into synaptic space, binding to different glutamatergic receptors, downstream signaling, uptake to astrocytes, conversion to glutamine, and shuttling glutamine back from astrocytes to neurons to produce glutamate again and repeat the cycle. Glutamatergic signaling intersects with cellular energy economy and with other critical processes, such as the labile iron pool and potentially ferroptosis. Current glutamatergic medications, such as ceftriaxone, riluzole, memantine, ketamine, topiramate, lamotrigine, N-acetylcysteine, and D-cycloserine, show efficacy in treating various disorders. However, other nodes along the glutamatergic signaling pathway and the intersecting pathways could theoretically provide potential targets for pharmacotherapy. This Special Issue aims to delve into the exciting world of glutamate and its intersecting pathways.
Dr. Osama Abulseoud
Prof. Dr. Frank Schmitz
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- glutamate glutamine cycle
- neurotoxicty
- ferroptosis
- hyperglutamatergic states
- innovative pharmacological interventions
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
