Unraveling the Role of the Relaxin-Like Peptide Family in Cancer: Mechanisms, Impacts and Therapeutic Potential
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 444
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cancer, a disease marked by uncontrolled cell growth, is influenced by a myriad of molecular and physiological factors, among which is the Relaxin-like peptide family (RLPF). Classified as RLN1-3 and INSL3-6 in humans, these peptides interact with G-protein-coupled receptors (GPCRs) to mediate a range of physiological actions. Recent findings indicate that the RLPF exhibits variable expression patterns across different cancer types, implicating its significant role in the progression and management of this disease.
In this Special Issue, titled "Unraveling the Role of the Relaxin-Like Peptide Family in Cancer: Mechanisms, Impacts and Therapeutic Potential", we seek to unravel the complex network of interactions between the RLPF and tumorigenic processes such as the proliferation, migration, invasion, and modulation of tumor and immune microenvironments and the development of anticancer resistance. A greater understanding of these dynamics will illuminate their impact on patient prognosis and potentially pave the way for the development of innovative therapeutic strategies targeting this interaction.
We warmly welcome original research focusing on the molecular mechanisms underlying the interaction of RLPF with tumors, the differential expression patterns of the RLPF across various cancer types, and the exploration of novel therapeutic approaches using this interaction. Furthermore, we invite comprehensive review articles that summarize recent advances in the understanding of RLPF in cancer, from cellular mechanisms to clinical implications.
Through this Special Issue, we aim to foster a deeper understanding of the role of the Relaxin-like peptide family in cancer, ultimately contributing to the enhancement of therapeutic strategies and patient care. We look forward to your valuable contributions to this intriguing and highly relevant field of research.
Dr. Hyunho Han
Guest Editor
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Keywords
- relaxin-like peptide family (RLPF)
- G protein-coupled receptor (GPCRs)
- cancer development
- tumorigenic processes
- tumor microenvironment
- immune microenvironment
- anticancer resistance
- molecular mechanisms
- therapeutic strategies
- patient prognosis
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