Molecular Mechanisms of Neurodegeneration: Signaling Pathways and Therapeutic Targets
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 13
Special Issue Editor
Interests: age-related degeneration; Alzheimer’s disease; brain resilience; cellular metabolism; genetics; immune signaling; microglia; neurodegeneration; neuroinflammation; oxidative stress; Parkinson’s disease; proteostasis; therapeutic targets
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and related disorders arise from the convergence of dysregulated molecular and cellular signaling networks that govern metabolism, lysosomal function, debris clearance, neuroinflammation, and synaptic integrity. Advances in genome-wide and functional genomic analyses, systems biology, and aging research have revealed that both genetic variants and age-related signaling alterations profoundly influence the molecular pathways underlying resilience, vulnerability, and disease progression.
In particular, signaling cascades mediated by genes such as APOE, TREM2, INPP5D, and PLCG2 have highlighted the therapeutic potential of modulating microglial and immune functions to restore brain homeostasis.
This Special Issue aims to highlight recent advances in elucidating the molecular and cellular mechanisms of neurodegeneration, with a focus on signaling pathways that represent promising therapeutic targets.
We welcome original research and review articles integrating genetics, multi-omics, cellular biology, and pharmacology to advance our understanding of the signaling networks that underlie neurodegenerative disease and brain resilience.
Dr. Andy P. Tsai
Guest Editor
Manuscript Submission Information
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Keywords
- neurodegeneration
- molecular signaling
- neuroinflammation
- cellular metabolism
- therapeutic targets
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