Molecular Mechanisms Safeguarding Genome Integrity in DNA Replication, Repair and Transcription

Dear Colleagues,

In recent years, knowledge on the cellular and molecular mechanisms underlying the maintenance of genome integrity has increased significantly through the identification of the signaling pathways and main players in the DNA damage response. Thanks to these advancements, crucial aspects of this important cell defense mechanism are currently being exploited, and new strategies to control abnormal cell proliferation and tumor formation are being developed. However, refined definitions of the processes involved in the DNA damage response, especially regarding their regulation, are needed to further this knowledge and identify new points of intervention. In particular, protein–protein interactions, as well as protein post-translation modifications are important components in unravelling the mechanisms responsible for the maintenance of genome stability. This Special Issue will focus on the latest research in the essential processes of DNA replication, repair, and transcription with the aim of advancing the knowledge of the roles of these molecular mechanisms in the DNA damage response.

Dr. Ornella Cazzalini
Dr. Ennio Prosperi
Guest Editors

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