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Special Issue "Nanostructured Drug Delivery Systems 2.0: Modeling, Preparation and Characterisation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 30 March 2024 | Viewed by 488

Special Issue Editors

MTA-SZTE Biomimetic Systems Research Group, Department of Medical Chemistry, University of Szeged, Dóm Square 8, H-6720 Szeged, Hungary
Interests: surface plasmon resonance; study of protein-ligand interactions by 2D and 3D techniques; protein-and polysaccharide-based colloidal drug carriers; surfactants
Special Issues, Collections and Topics in MDPI journals
MTA-SZTE Lendület “Momentum” Noble Metal Nanostructures Research Group, University of Szeged, Rerrich B. Sqr. 1, H-6720 Szeged, Hungary
Interests: plasmonic mono- and bimetallic nanoparticles; fluorescent gold-based nanostructures; serum protein- and polymer-based colloidal drug delivery systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanostructured objects are systems with one or more dimensions or features reduced to the nanoscale, presenting some unique and sometimes unprecedented physicochemical properties. The possibility of manipulating and regulating these properties makes them suitable for a variety of nanomedical applications. In recent years, low-dimensional structures with specific advanced functional properties have attracted extremely extensive research interest in pharmaceutical and healthcare fields. The nano-encapsulation of drugs or nutrients is a promising and broadly applied formulation technology that enables several interesting novel delivery concepts. Despite decades of technical development, nanostructured materials face considerable challenges in bringing them closer to successful and widespread practical application.

The aim of this Special Issue of the International Journal of Molecular Sciences is to bring together original and high-quality research papers covering the most recent advances as well as comprehensive reviews addressing state-of-the-art topics in the field of the design, synthesis, and chemical/physicochemical characterization of nanostructured drug delivery systems.

Preferred topics:

  • Modeling of drug–carrier interactions by advanced measuring methods;
  • Design and synthesis of biocompatible and nanostructured drug delivery particles;
  • Application of hydrogels, aerogels and polymer/surfactant associates as drug carriers;
  • Characterisation and modification of the drug dissolution process;
  • Encapsulation and controlled release of proteins, vitamins and minerals.

In advance, I would like to gratefully acknowledge the authors and reviewers who will participate to the elaboration of this Special Issue and that will contribute to the development of research based on the nanostructured drug delivery systems.

Dr. Ádám Juhász
Dr. Edit Csapó
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nanostructured materials
  • drug delivery
  • drug-carrier interactions
  • hydrogel
  • aerogels
  • associated colloids
  • surfactants
  • macromolecules
  • porous materials
  • hybrid materials
  • controlled release

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Published Papers (1 paper)

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Lipid-Based Nanocarriers for Delivery of Neuroprotective Kynurenic Acid: Preparation, Characterization, and BBB Transport
Int. J. Mol. Sci. 2023, 24(18), 14251; https://doi.org/10.3390/ijms241814251 - 18 Sep 2023
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Encapsulation possibilities of an extensively investigated neuroprotective drug (kynurenic acid, KYNA) are studied via lipid-based nanocarriers to increase the blood–brain barrier (BBB) specific permeability. The outcomes of various preparation conditions such as stirring and sonication time, concentration of the lipid carriers and the [...] Read more.
Encapsulation possibilities of an extensively investigated neuroprotective drug (kynurenic acid, KYNA) are studied via lipid-based nanocarriers to increase the blood–brain barrier (BBB) specific permeability. The outcomes of various preparation conditions such as stirring and sonication time, concentration of the lipid carriers and the drug, and the drug-to-lipid ratio are examined. Considering the experimentally determined encapsulation efficiency, hydrodynamic diameter, and ζ-potential values, the initial lipid and drug concentration as well as the stirring and sonication time of the preparation were optimized. The average hydrodynamic diameter of the prepared asolectin-(LIP) and water-soluble lipopolymer (WSLP)-based liposomes was found to be ca. 25 and 60 nm under physiological conditions. The physicochemical characterization of the colloidal carriers proves that the preparation of the drug-loaded liposomes was a successful process, and secondary interactions were indicated between the drug molecule and the polymer residues around the WSLP membrane. Dissolution profiles of the active molecule under physiological conditions were registered, and the release of the unformulated and encapsulated drug is very similar. In addition to this outcome, the in vitro polar brain lipid extract (porcine)-based permeability test proved the achievement of two- or fourfold higher BBB specific penetration and lipid membrane retention for KYNA in the liposomal carriers relative to the unformatted drug. Full article
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