Extracellular Vesicles and Their Role in Immunomodulation and Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 10263
Special Issue Editor
Special Issue Information
Dear Colleagues,
Today, a great deal of evidence has shown the critical role of extracellular vesicles (EVs) in tumor progression and host immune response. Among different subtypes of EVs, categorized mainly based on their size, small EVs, also known as exosomes, have been at the center of attention in recent years due to their ever-expanding role in tumor metastasis and drug resistance, as well as the modulation of antitumor immune responses. In this context, exosomes have been shown to be capable of both stimulating and dampening antitumor immune responses, making them a double-edged sword in cancer management. Furthermore, the absence of a consensus on specific markers for the identification of exosomes adds to the complexity of their study and opens up a potential area for future cancer research. In addition to their potential for therapeutic targeting in cancer, there is growing evidence for the potential of exosomes as rich sources of diagnostic markers, which provide superior advantages as sources of cancer biomarkers for liquid-biopsy-based assays. Accordingly, a Special Issue entitled “Extracellular Vesicles and Their Role in Immunomodulation and Cancer” is launched to call forth scientists from all over the world to contribute their latest high-quality research for a better understanding of the field. Indeed, the successful completion of this Special Issue will spread the latest advances in the field to a wide readership.
In this Special Issue, rigorously prepared original research papers and critical reviews presenting novel findings on the most recent aspects of the field are welcome. The topics covered in this Special Issue include, but are not limited to:
- EVs as modulators of the tumor microenvironment and the immune response.
- Differences among EV sources and their biological relevance.
- Engineering EV-producing cells as a tool for EV modification.
- The prognostic and diagnostic potential of EVs as sources of immune markers in cancer.
Dr. Milad Moloudizargari
Guest Editor
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Keywords
- extracellular vesicles
- cancer immunology
- exosomes
- tumor-derived exosomes
- tumor escape
- immunomodulation
- immunotherapy
- multiple myeloma
- tumor microenvironment
- diagnosis
- biomarker
- natural killer cells
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