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Adenosine Receptor and Cardiovascular Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1518

Special Issue Editor

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Guest Editor
Director of the Institute of Pharmacology and Toxicology, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, 06120 Halle (Saale), Germany
Interests: dopamine; histamine; proteinphosphatases; heart failure; arrhythmias; serotonin
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Special Issue Information

Dear Colleagues,

This Special Issue focuses on the signal transduction of P1 and P2 receptors in the heart with regard to health and diseases. Moreover, the ways in which new P1 or P2 receptor agonists and antagonists behave in the heart is of interest. Another interesting field to explore is the presence and functional role of homomeric and heterodimeric P1 and P2 receptors in the heart. Studies that present a pathophysiological standpoint regarding the role of these receptors in common cardiac diseases—such as heart failure (pressure-induced, sepsis-induced, volume-overload-induced, genetically induced), hypertension, and supraventricular or ventricular arrhythmias—will be considered for publication in this Special Issue. These studies can be carried out in patients, isolated human cardiac preparations, and animal cardiomyocytes, especially from transgenic mouse models. Biochemical and electrophysiological studies are also encouraged.

Prof. Dr. Joachim Neumann
Guest Editor

Manuscript Submission Information

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  • P1 receptors
  • P2 receptors
  • heart
  • vessel
  • heart failure
  • hypertension
  • arrhythmias

Published Papers (1 paper)

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12 pages, 1705 KiB  
Expression and Impact of Adenosine A3 Receptors on Calcium Homeostasis in Human Right Atrium
by Carmen Tarifa, Verónica Jiménez-Sábado, Rafael Franco, José Montiel, José Guerra, Francisco Ciruela and Leif Hove-Madsen
Int. J. Mol. Sci. 2023, 24(5), 4404; https://doi.org/10.3390/ijms24054404 - 23 Feb 2023
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Increased adenosine A2A receptor (A2AR) expression and activation underlies a higher incidence of spontaneous calcium release in atrial fibrillation (AF). Adenosine A3 receptors (A3R) could counteract excessive A2AR activation, but their functional role in the [...] Read more.
Increased adenosine A2A receptor (A2AR) expression and activation underlies a higher incidence of spontaneous calcium release in atrial fibrillation (AF). Adenosine A3 receptors (A3R) could counteract excessive A2AR activation, but their functional role in the atrium remains elusive, and we therefore aimed to address the impact of A3Rs on intracellular calcium homeostasis. For this purpose, we analyzed right atrial samples or myocytes from 53 patients without AF, using quantitative PCR, patch-clamp technique, immunofluorescent labeling or confocal calcium imaging. A3R mRNA accounted for 9% and A2AR mRNA for 32%. At baseline, A3R inhibition increased the transient inward current (ITI) frequency from 0.28 to 0.81 events/min (p < 0.05). Simultaneous stimulation of A2ARs and A3Rs increased the calcium spark frequency seven-fold (p < 0.001) and the ITI frequency from 0.14 to 0.64 events/min (p < 0.05). Subsequent A3R inhibition caused a strong additional increase in the ITI frequency (to 2.04 events/min; p < 0.01) and increased phosphorylation at s2808 1.7-fold (p < 0.001). These pharmacological treatments had no significant effects on L-type calcium current density or sarcoplasmic reticulum calcium load. In conclusion, A3Rs are expressed and blunt spontaneous calcium release at baseline and upon A2AR-stimulation in human atrial myocytes, pointing to A3R activation as a means to attenuate physiological and pathological elevations of spontaneous calcium release events. Full article
(This article belongs to the Special Issue Adenosine Receptor and Cardiovascular Disorders)
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