Impact of Signaling Pathways on Endothelial Cells: From Homeostasis to Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 1365
Special Issue Editor
Special Issue Information
Dear Colleagues,
Endothelial cells receive continuous molecular inputs from blood and surrounding tissues, and secrete, in turn, angiocrine factors that regulate tissue homeostasis and development. Dysregulation in the communication between endothelial cells and surrounding tissues is involved in numerous pathologies. Recent advances in vascular biology have revealed that unique combinations of signaling pathways and hemodynamics define the endothelial microenvironments motivating and supporting endothelial cell heterogeneity, not only between organs, but also within a given organ. This inherent endothelial heterogeneity is key for blood and lymphatic vessel development, function and regeneration. Thus, an enhanced understanding of how signaling pathways and hemodynamics affect the growth and maintenance of blood and lymphatic vessels of different organs, sizes and morphologies is required in order to engineer the vascularization of organoids or regenerating tissues, and to normalize vascular and lymphatic malformations.
In this Special Issue of the International Journal of Molecular Sciences, we aim to publish original research works focusing on endothelial signaling pathways in health and diseases. Please note that the International Journal of Molecular Sciences is a journal of molecular science, and thus pure clinical or model studies will not be suitable. However, clinical or pure model submissions alongside biomolecular experiments are welcome.
Dr. Nicolas Ricard
Guest Editor
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Keywords
- endothelial cells
- signaling pathways
- endothelial homeostasis
- vascular diseases
- vascular malformations
- lymphatic malformations
- endothelial heterogeneity
- intercellular communication
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