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The Role of Gut Microbiota and Immune Responses in the Pathogenesis of IBD

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (26 February 2024) | Viewed by 1206

Special Issue Editors

1. Broad Institute of MIT and Harvard, Harvard, MA, USA
2. Harvard Medical School and Massachusetts General Hospital, Harvard, MA, USA
Interests: gut microbiota; host-pathogen interactions

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Guest Editor
Department of Parasitology, College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China
Interests: parasites; genetics; genomics; population structure; epidemiology; host–parasite interaction
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Guest Editor
Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China
Interests: arthropods and arthropod-borne pathogens; interaction of pathogen-vector-host; mechanism for invasion of host cells; serological and molecular diagnostic tools for tick-borne diseases; detection of pathogens in vector ticks; vaccine development for ticks; tick-borne diseases; infectious diseases

Special Issue Information

Dear Colleagues,

Inflammatory bowel disease (IBD) is a chronic and debilitating disease of the gastrointestinal tract that affects millions of people worldwide. While the exact cause of IBD remains unknown, recent research has highlighted the critical role of the gut microbiota and immune responses in its pathogenesis. Dysbiosis, or an imbalance in the composition of the gut microbiota, has been shown to disrupt the immune responses that maintain gut homeostasis, leading to chronic inflammation and tissue damage. The interplay between gut microbiota and the immune system is therefore a key area of research in IBD, with the potential to yield novel therapeutic approaches for the treatment of this complex disease.

This Special Issue aims to provide a comprehensive overview of the latest advances in the field of gut microbiota and immune responses in IBD. We invite original research articles, reviews, and perspectives that explore the mechanisms underlying the dysbiosis of the gut microbiota in IBD, the interactions between gut microbiota and the immune system in IBD, and the potential therapeutic interventions that target the gut microbiota and immune responses in IBD. Topics of interest include but are not limited to:

  1. The gut microbiota and immune system interactions in IBD;
  2. The role of gut-microbiota-derived metabolites in IBD pathogenesis;
  3. The effects of diet and lifestyle on the gut microbiota and immune system in IBD;
  4. Emerging therapies targeting the gut microbiota and immune system in IBD.

Dr. Lei Deng
Prof. Dr. Guanghui Zhao
Prof. Dr. Hong Yin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

18 pages, 1386 KiB  
Review
Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel Disease
by Salvinaz Islam Moutusy and Seiichiroh Ohsako
Int. J. Mol. Sci. 2024, 25(6), 3372; https://doi.org/10.3390/ijms25063372 - 16 Mar 2024
Viewed by 939
Abstract
Inflammatory bowel disease (IBD) is one of the most prevalent chronic inflammations of the gastrointestinal tract (GIT). The gut microbial population, the cytokine milieu, the aryl hydrocarbon receptor (AHR) expressed by immune and nonimmune cells and the intrinsic pathway of Th-cell differentiation are [...] Read more.
Inflammatory bowel disease (IBD) is one of the most prevalent chronic inflammations of the gastrointestinal tract (GIT). The gut microbial population, the cytokine milieu, the aryl hydrocarbon receptor (AHR) expressed by immune and nonimmune cells and the intrinsic pathway of Th-cell differentiation are implicated in the immunopathology of IBD. AHR activation requires a delicate balance between regulatory and effector T-cells; loss of this balance can cause local gut microbial dysbiosis and intestinal inflammation. Thus, the study of the gut microbiome in association with AHR provides critical insights into IBD pathogenesis and interventions. This review will focus on the recent advancements to form conceptional frameworks on the benefits of AHR activation by commensal gut bacteria in IBD. Full article
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