The Regulation of the Cytoskeleton in the Healthy and Diseased Central Nervous System 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 1903
Special Issue Editor
Interests: actin cytoskeleton; microtubules; Alzheimer’s disease; motor neuron disease; neurite growth
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The regulation of the cell architecture and particularly the cytoskelelton plays a pivotal role in controlling neuronal connectivity and neuronal function in the central nervous system (CNS). For a long time, changes in the cytoskeletal organisation of neurons has been considered to be largely a byproduct in the pathology of CNS diseases. However, the disruption of the regluatory mechanisms of the cell architecture has been increasingly implicated in the pathogenesis of a large number of neurological and neurodegenerative diseases and CNS injuries, including Alzheimer’s disease, motor neuron disease, epilepsy, schizphrenia, brain trauma and spinal cord injury. Gaining a detailed understanding of the physiological regulation of the cytoskeleton as well as the disease-associated alterations of its regulation will be crucial to develop new therapeutic approaches of dieases that affect the CNS. This Special Issue aims to feature recent advances in the field, of studying the cytoskeleton in the healthy and dieased nervous system. For this, we are welcoming original resarch article and review contributions, discussing the fundamental regulation of the cytoskeleton in neurons and glial cells in the brain and spinal cord, the molecular basis of disease-associated pathomechanisms of CNS diseases and the use of cytoskeletal building blocks as biomarkers and as drug targets in CNS diseases.
Prof. Dr. Thomas Fath
Guest Editor
Manuscript Submission Information
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Keywords
- actin cytoskeleton
- microtubules
- intermediate filaments
- neurodegenerative diseases
- Alzheimer’ disease
- motor neuron disease
- spinal cord injury
