Molecular Mechanisms of Genetic and Acquired Acid-Base Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 49
Special Issue Editor
2. Research Services, Raymond J. Murphy Veterans Health Care Center, Albuquerque, NM 87108, USA
Interests: kidney; nephrology; acute kidney injury; hypertension; acid base and electrolyte transport; renal tubular acidosis; metabolic alkalosis; cloning and characterization of acid base transporters
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The systemic acid–base balance is tightly regulated at an arterial pH range of 7.36–7.44, and the intracellular pH is ~7.2. This narrowly regulated pH is critical for the normal functioning of every cell and tissue in the body, including cardiovascular, neuronal, endocrine, kidney, and pulmonary function. The two major organs responsible for a balanced systemic pH are the kidney and lung, which regulate serum HCO3- and pCO2, respectively.
The kidney is essential for maintaining the blood HCO3- concentration in a narrow range through a number of physiologic and biochemical processes, which include the reabsorption of filtered HCO3-, the generation of new HCO3-, the secretion of HCO3-, ammoniagenesis, and the production of protons, leading to H+ or HCO3- transport in various tubules. These processes are critical for preventing acidosis or alkalosis, conditions that can disrupt metabolic functions and lead to serious health issues. Similarly, the lung plays a pivotal role in managing carbon dioxide levels, facilitating gas exchange that helps stabilize the body's acid–base balance. Other organs such as the liver, pancreas, stomach, adrenal glands, and intestines significantly contribute to systemic acid–base homeostasis.
Studies over the last four decades have identified the molecular mechanisms and pathways responsible for acid–base homeostasis, which include the generation and secretion of acid (H+) and the absorption or secretion of HCO₃⁻ in kidney tubules as well as in other epithelial tissues, encompassing the pulmonary system (e.g. trachea and alveolar cells) and gastrointestinal tract (e.g., pancreatic, hepatic, gastric, and intestinal tract).
Acid–base disorders can primarily manifest with metabolic acidosis or metabolic alkalosis, and encompass diverse diseases ranging from proximal renal tubular acidosis to distal renal tubular acidosis, cystic fibrosis, hyperkalemia, hypokalemia, hypertension, secretory and osmotic diarrhea, and malabsorption, among other diseases. These disorders can either be acquired or inherited.
This Special Issue of the IJMS focuses on publishing a collection of state-of-the-art original and high-quality review articles that define the current status of the molecular mechanisms of acid–base disorders with the eventual aim of fostering collaboration among scientists and clinicians.
Prof. Dr. Manoocher Soleimani
Guest Editor
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Keywords
- acid–base balance
- bicarbonate transport
- metabolic acidosis
- metabolic alkalosis
- renal tubular acidosis
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