Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
cGMP Signaling: From Bench to Bedside
ijms-logo
Submit to Special Issue Submit Abstract to Special Issue Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

cGMP Signaling: From Bench to Bedside

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 2554

Special Issue Editor

Dr. Iraida Sharina

E-Mail Website
Guest Editor
Department of Internal Medicine/Cardiology, UT-Houston McGovern Medical School, Houston, TX, USA
Interests: cGMP signaling; sGC activity and regulation; NO/cGMP

Special Issue Information

Dear Colleagues,

Soluble guanylyl cyclase (sGC) was originally discovered as a cellular receptor for gaseous secondary messenger Nitric Oxide (NO). Upon binding of the NO molecule to sGC heme, the sGC enzyme activates the conversion of GTP to ubiquitous secondary messenger cGMP thereby multiplying and propagating downstream signaling of the cascade. Since the original discovery of sGC’s role in vascular regulation, NO/cGMP-signaling importance was demonstrated in a multitude of physiological and pathophysiological processes. The critical role sGC plays in the homeostasis of the cardiovascular, pulmonary, gastrointestinal, renal and neuronal systems established this enzyme as a prominent therapeutic target. Currently, a growing number of sGC-targeting drugs to combat various diseases has been identified and tested in various disease models or clinical trials.

This Special Issue will explore emerging applications of sGC targeted therapeutics to modulate NO/cGMP signaling activity to tackle an array of new diseases such as ischemia, fibrosis and cancer proliferation, to name a few. Research articles/reviews related to this topic are welcome in this issue.

Dr. Iraida Sharina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nitric oxide
  • cellular signaling
  • cardiovascular biology
  • cerebrovascular regulation
  • aging

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

13 pages, 4818 KiB  
Article
The α1- and β1-Subunits of Nitric Oxide-Sensitive Guanylyl Cyclase in Pericytes of Healthy Human Dental Pulp
by Yüksel Korkmaz, Galyna Pryymachuk, Mechthild M. Schroeter, Behrus Puladi, Nadin Piekarek, Sarah Appel, Wilhelm Bloch, Jan-Wilm Lackmann, James Deschner and Andreas Friebe
Int. J. Mol. Sci. 2025, 26(1), 30; https://doi.org/10.3390/ijms26010030 - 24 Dec 2024
Viewed by 751
Abstract
Nitric oxide-sensitive guanylyl cyclase (NO-GC) is a heterodimeric enzyme with an α- and a β-subunit. In its active form as an α1β1-heterodimer, NO-GC produces cyclic guanosine-3′,5′-monophophate (cGMP) to regulate vasodilation and proliferation of vascular smooth muscle cells (VSMCs). In [...] Read more.
Nitric oxide-sensitive guanylyl cyclase (NO-GC) is a heterodimeric enzyme with an α- and a β-subunit. In its active form as an α1β1-heterodimer, NO-GC produces cyclic guanosine-3′,5′-monophophate (cGMP) to regulate vasodilation and proliferation of vascular smooth muscle cells (VSMCs). In contrast to VSMCs, only a few studies reported on the expression of the NO-GC α1β1-heterodimer in human pericytes. Since NO-GC is a marker for platelet-derived growth factor-β (PDGFRβ)-positive pericytes, we investigated whether NO-GC is expressed in its active α1β1-heterodimer in pericytes of healthy human dental pulp. In our previous studies, we developed and validated an antibody against the α1-subunit of human NO-GC. Here, we developed a new antibody against the β1-subunit of human NO-GC and validated it by immunoblot, mass spectrometry, and immunohistochemistry on tissue samples from humans and NO-GC knockout (GCKO) mice. Using both antibodies, we detected α1- and β1-subunits of NO-GC in pericytes of pre-capillary arterioles, capillaries, and post-capillary venules in dental pulp of decalcified and non-decalcified human molars. We concluded that NO-GC as an active α1β1-heterodimer may be involved in the regulation of vascular permeability, vascular stability, organ homeostasis, and organ regeneration in healthy human dental pulp. Full article
(This article belongs to the Special Issue cGMP Signaling: From Bench to Bedside)
►▼ Show Figures

Figure 1

Review

Jump to: Research

25 pages, 3622 KiB  
Review
Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer
by María Teresa L. Pino, María Victoria Rocca, Lucas H. Acosta and Jimena P. Cabilla
Int. J. Mol. Sci. 2024, 25(18), 10053; https://doi.org/10.3390/ijms251810053 - 19 Sep 2024
Viewed by 1200
Abstract
Since the discovery of nitric oxide (NO), a long journey has led us to the present, during which much knowledge has been gained about its pathway members and their roles in physiological and various pathophysiological conditions. Soluble guanylyl cyclase (sGC), the main NO [...] Read more.
Since the discovery of nitric oxide (NO), a long journey has led us to the present, during which much knowledge has been gained about its pathway members and their roles in physiological and various pathophysiological conditions. Soluble guanylyl cyclase (sGC), the main NO receptor composed of the sGCα1 and sGCβ1 subunits, has been one of the central figures in this narrative. However, the sGCα1 and sGCβ1 subunits remained obscured by the focus on sGC’s enzymatic activity for many years. In this review, we restore the significance of the sGCα1 and sGCβ1 subunits by compiling and analyzing available but previously overlooked information regarding their roles beyond enzymatic activity. We delve into the basics of sGC expression regulation, from its transcriptional regulation to its interaction with proteins, placing particular emphasis on evidence thus far demonstrating the actions of each sGC subunit in different tumor models. Exploring the roles of sGC subunits in cancer offers a valuable opportunity to enhance our understanding of tumor biology and discover new therapeutic avenues. Full article
(This article belongs to the Special Issue cGMP Signaling: From Bench to Bedside)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop