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Neuroendocrinology Across Time

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 December 2024) | Viewed by 1554

Special Issue Editor


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Guest Editor
1. Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), São Luis 65020-070, Brazil
2. Postgraduate Program in Health Sciences, Federal University of Maranhão, São Luis 65080-805, Brazil
3. Clinical Research Center, University Hospital, Federal University of Maranhão, São Luis 65020-070, Brazil
Interests: connexins; pituitary neuroendocrine tumors; apoptosis

Special Issue Information

Dear Colleagues,

Neuroendocrinology is the study of interactions between hormones and the brain, primarily focusing on how hormones affect behavior. Pituitary adenoma (PA) is not a simple resectable benign tumor but a complex neuroendocrine disease with a very high incidence and relatively common intracranial neoplasms; it is usually benign, but occasionally exhibits aggressive behavior and is very rarely malignant.

Pituitary tumors can be either secretory (secreting excessive pituitary hormones) or non-functioning (non-secreting). Pituitary tumor symptoms may be caused by a tumor putting pressure on the brain or on other parts of the body nearby. Symptoms also can be caused by a hormone imbalance. This Special Issue provides contemporary insights into various aspects of PA, with an emphasis on the molecular understanding of tumor pathogenesis and on molecular advancements in the radiological, histopathological, genetic, and personalized use of emerging therapies.

Dr. Manuel Dos Santos Faria
Guest Editor

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Keywords

  • neuroendocrine
  • pituitary gland
  • pituitary tumorigenesis
  • pituitary biomarkers
  • pituitary dysfunction
  • pituitary treatment

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Published Papers (1 paper)

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Research

12 pages, 493 KiB  
Article
Relationship Between C-Peptide Levels, Clinical Features, and Serum Data in a Brazilian Type 1 Diabetes Population with Large Variations in Genomic Ancestry
by Rossana Sousa Azulay, Vandilson Rodrigues, Débora Cristina Ferreira Lago, Ana Gregória Ferreira Pereira de Almeida, Joana D’Arc Matos França de Abreu, Lincoln Matos, Caio Andrade, Gilvan Cortês Nascimento, Marcelo Magalhães, Alexandre Facundo, Clariano Pires de Oliveira Neto, Adriana Guimarães Sá, Dayse Aparecida Silva, Marília Brito Gomes and Manuel dos Santos Faria
Int. J. Mol. Sci. 2024, 25(20), 11144; https://doi.org/10.3390/ijms252011144 - 17 Oct 2024
Cited by 1 | Viewed by 1312
Abstract
Type 1 diabetes (T1D) is a chronic disease characterized by the immune-mediated destruction of the pancreatic beta cells responsible for insulin production. The secreted insulin and C-peptide are equimolar. Due to its longer half-life, C-peptide has become a safer means of assessing the [...] Read more.
Type 1 diabetes (T1D) is a chronic disease characterized by the immune-mediated destruction of the pancreatic beta cells responsible for insulin production. The secreted insulin and C-peptide are equimolar. Due to its longer half-life, C-peptide has become a safer means of assessing the pancreatic reserve. C-peptide levels were evaluated in a population of patients with T1D, focusing on the relationship between this variable and other factors. In addition, the influence of C-peptide on metabolic control and microvascular complications was investigated. This cross-sectional study included 95 patients who had been diagnosed with T1D at least five years earlier. These patients were evaluated using a clinical demographic survey, anthropometric data, laboratory tests, and fundoscopy. This study showed that 29.5% of patients had residual insulin secretion, which correlated directly with their age at diagnosis. No statistically significant differences in metabolic control or microvascular complications were observed between the C-peptide level groups. In addition, our results indicate that ancestry does not influence the persistence of residual C-peptide function in our highly mixed population. It is recommended that future research consider incorporating new variables, such as HLA and pancreatic autoimmunity, as factors that may influence residual β-cell function. Full article
(This article belongs to the Special Issue Neuroendocrinology Across Time)
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