ijms-logo

Journal Browser

Journal Browser

Advances in Developmental Neurotoxicology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 1466

Special Issue Editor


E-Mail Website
Guest Editor
UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
Interests: molecular toxicology; developmental neurotoxicology; new psychoactive substances; cannabinoids; oxidative stress
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Humans are daily exposed to toxic substances that may affect the nervous system. The developing brain is particularly vulnerable, compared to the adult brain, to toxicants exposure, due to the complex network of events occurring during brain development (e.g., neuronal/glia differentiation, migration, maturation, synaptogenesis, blood-brain barrier immaturity). Moreover, neurodevelopmental impairment has been increasingly correlated with neurodevelopmental disorders (e.g., autism, attention deficit hyperactivity disorder), making the mechanistic understanding of how toxicants may affect the developing brain highly relevant. Notably, developmental neurotoxicity assessment remains quite challenging, as the developmental outcomes depend on the substance, type of exposure, and the brain’s developmental stage at the time of exposure. This Special Issue welcomes reviews and original research contributions on the most recent advances in developmental neurotoxicology, including, but not limited, to the following topics:

  • Molecular mechanisms underlying the adverse effects of exposure to toxicants (g., pesticides, biocides, industrial chemicals, heavy metals, pharmaceuticals, substances of abuse, or nanomaterials) during neurodevelopment;
  • Cognitive and behavioral outcomes following exposure to toxicants during neurodevelopment;
  • Identification of new biomarkers of neurodevelopmental neurotoxicity that may be used as diagnostic tools or therapeutic targets for neurodevelopmental disorders;
  • New and improved models (g., in silico, in vitro, in vivo) for testing developmental neurotoxicity.

This Special Issue is supervised by Dr. João Pedro Silva and assisted by our Topical Advisory Panel Member Dr. Ana Filipa Sobral,  (University Institute of Health Sciences).

Dr. João Pedro Silva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • developmental neurotoxicology
  • neurodevelopmental models
  • neurotoxicants
  • neurodevelopmental disorders

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 6602 KiB  
Article
Neurotoxicity and Developmental Neurotoxicity of Copper Sulfide Nanoparticles on a Human Neuronal In-Vitro Test System
by Michael Stern, Nandipha Botha, Karen J. Cloete, Malik Maaza, Saime Tan and Gerd Bicker
Int. J. Mol. Sci. 2024, 25(11), 5650; https://doi.org/10.3390/ijms25115650 - 22 May 2024
Cited by 1 | Viewed by 844
Abstract
Nanoparticles (NPs) are becoming increasingly important novel materials for many purposes, including basic research, medicine, agriculture, and engineering. Increasing human and environmental exposure to these promising compounds requires assessment of their potential health risks. While the general direct cytotoxicity of NPs is often [...] Read more.
Nanoparticles (NPs) are becoming increasingly important novel materials for many purposes, including basic research, medicine, agriculture, and engineering. Increasing human and environmental exposure to these promising compounds requires assessment of their potential health risks. While the general direct cytotoxicity of NPs is often routinely measured, more indirect possible long-term effects, such as reproductive or developmental neurotoxicity (DNT), have been studied only occasionally and, if so, mostly on non-human animal models, such as zebrafish embryos. In this present study, we employed a well-characterized human neuronal precursor cell line to test the concentration-dependent DNT of green-manufactured copper sulfide (CuS) nanoparticles on crucial early events in human brain development. CuS NPs turned out to be generally cytotoxic in the low ppm range. Using an established prediction model, we found a clear DNT potential of CuS NPs on neuronal precursor cell migration and neurite outgrowth, with IC50 values 10 times and 5 times, respectively, lower for the specific DNT endpoint than for general cytotoxicity. We conclude that, in addition to the opportunities of NPs, their risks to human health should be carefully considered. Full article
(This article belongs to the Special Issue Advances in Developmental Neurotoxicology)
Show Figures

Figure 1

Back to TopTop