Advances in the Study of Cell Cycle
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (28 September 2023) | Viewed by 24359
Special Issue Editor
Special Issue Information
Dear Colleagues,
The cell cycle is divided into two fundamental phases: interphase and mitosis. In the interphase, cells replicate their genome. Preceded by the G1 gap phase, the S phase occurs, and chromosomes are replicated and followed by the G2 gap phase. Through the interphase, G1/S checkpoint and S phase checkpoint, and G2 checkpoint control cell cycle progression to ensure error-free genomes. In mitosis, duplicated genomes are segregated into daughter cells, resulting in the completion of the cell cycle. Mitosis coordinates the cell architecture to segregate the proper number of chromosomes and divide the cells. The spindle assembly checkpoint maintains the chromosome number, and the cytokinesis checkpoint coordinates chromosome segregation and cell division for the next cell cycle.
The growth and development of an organism are closely related to cell cycle regulation, e.g., the development of a fertilized egg. Tight regulations via cell cycle progression and checkpoint machinery ensure the maintenance of the genome and prevent aberrant cell cycle progression. The nature of molecular mechanisms that regulate the progression of the cell cycle has been identified; dysregulation of this process can lead to diseases, including cancer and degenerative disorders. However, understanding the mechanisms operating in the cell division cycle is still required. In this Special Issue, we focus on regulator proteins contributing to the control of the cell cycle.
We invite original research papers and reviews discussing updates on cell cycle machinery and cell cycle checkpoint mechanisms. Papers and reviews on cell cycle regulation in the developmental stages and meiotic cell cycle regulation, and tissue-specific cell cycle regulation are also welcomed. Finally, we encourage the submission of manuscripts focusing on defects in cell cycle checkpoints in cancer and diseases. We look forward to your contributions.
Dr. Toshiyuki Habu
Guest Editor
Manuscript Submission Information
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Keywords
- cell cycle machinery
- cell cycle checkpoint mechanism
- DNA damage checkpoint
- cell cycle regulation in the developmental stages
- meiotic cell cycle regulation
- tissue-specific cell cycle regulation
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