Challenges and Future Trends of Hepatocellular Carcinoma Immunotherapy, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 5309
Special Issue Editor
Interests: hepatocellular carcinoma; immunotherapy; gastric cancer; HCC; renal cell carcinoma; urothelial carcinoma; biliary tract cancer; cholangiocarcinoma
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Emerging immune checkpoint inhibitors (ICIs) have also made progress in HCC, with two PD-1 inhibitors—nivolumab and pembrolizumab—both being approved by the United States Food and Drug Administration (FDA). ICIs alone as a first-line treatment have not achieved the desired effect; however, clinical trials evaluating combinatorial strategies involving ICIs and other anticancer agents, especially antiangiogenic agents, have produced more compelling results, marking a new era in HCC management. The Practice-Changing Phase III IMbrave150 Trial compared the use of a combination of the PD-L1 inhibitor atezolizumab and bevacizumab versus sorafenib monotherapy in treatment-naïve patients with advanced HCC and showed that combination therapy resulted in higher median overall survival (OS), median progression-free survival (PFS) benefit, and overall response rate (ORR). Atezolizumab–bevacizumab is also currently recognized as the new standard of care in front-line HCC and has been approved for use in several countries worldwide. Similarly, other combinations have been tested and are currently being evaluated.
From this point of view, this Special Issue welcomes basic research, reviews, case reports, etc., on the current state of the art in the immunotherapy of HCC.
Potential topics include, but are not limited to:
- Translational research;
- Molecular experiments on novel immune-based combinations;
- Real-world experience with immune checkpoint inhibitors;
- Fighting resistance to immune checkpoint inhibitors;
- Biomarker-driven studies.
Dr. Angela Dalia Ricci
Guest Editor
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Keywords
- liver cancer
- hepatocellular carcinoma
- immunotherapy
- immune checkpoint inhibitors
- atezolizumab
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