Noble Gases and Gas Transmitters as Therapeutic and Preventive Molecules
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 4667
Special Issue Editor
Interests: cardiology; biophysics; electrophysiology; intracellular signaling systems; ion transport; molecular biology; telemedicine; innovation; nanotechnology
Special Issue Information
Dear Colleagues,
Several gaseous molecules have been demonstrated as potential therapeutic, preventive, and diagnostic agents. Protocols of hundreds of clinical trials have been registered at ClinicalTrials.gov, suggesting a high implementation potential for gaseous agents. Administration of noble gases (He, Ar, and Xe), gas transmitters (CO, H2S, and NO), and some other deliverable gases (H2, O2, O3, and N2O) result in the functional improvement in various organs and tissues. Xenon, argon, nitric oxide, carbon monoxide, and hydrogen sulfide exert putative neuroprotective and cardioprotective properties in different conditions ranging from cardiac-pulmonary bypass surgery and ischemia-reperfusion injury to alcohol-seeking behavior. The mechanistic basis of noble gas- and gas transmitter-medicated organ protection involves the modulation of oxidative stress, inflammatory responses, apoptotic processes, cell survival, and tissue repair. However, further efforts are needed to elucidate the entire spectrum of biological effects of gaseous molecules with promising therapeutic potential with especial attention to their possible toxicity and adverse reactions. Authors are invited to contribute to this Special Issue focusing on the mechanisms of protective effects exerted by gaseous molecules, their biological effects, signaling pathways, molecular targets, tissue distribution, biotransformation, preconditioning regimes, potential toxicity, and novel technologies of delivery.
Dr. Nina D. Anfinogenova
Guest Editor
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Keywords
- noble gases
- gas transmitters
- cardiology
- electrophysiology
- neuroprotection
- cardioprotection
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