Stem Cell Dynamics in Development and Regeneration
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 19
Special Issue Editors
Interests: stem cells; tissue engineering; systems biology; regenerative medicine; medical biotechnology
Special Issues, Collections and Topics in MDPI journals
Interests: bioceramics; biomaterials evaluation techniques; biological molecule adsorption to surfaces; tissue engineering; stem cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue, ‘Stem Cell Dynamics in Development and Regeneration’, is dedicated to advancing our understanding of how stem cells orchestrate processes of growth, repair, and renewal across the human lifespan. Stem cells represent a unique biological nexus: they are fundamental to embryonic development, while also serving as reservoirs for regeneration and repair in adulthood. Their dual role places them at the heart of both developmental biology and regenerative medicine.
Emerging studies reveal that stem cell behaviour is highly dynamic, shaped by intrinsic programmes, extracellular cues, and interactions within their microenvironment. These dynamics not only underpin tissue formation and patterning during development, but also influence the efficacy of regenerative therapies in degenerative disorders. By integrating basic biology with translational science, stem cell research is driving a new era of innovation with profound clinical implications.
We invite contributions that explore recent advances in the molecular and cellular regulation of stem cells, their role in modelling development and disease, and their therapeutic applications. Areas of interest include, but are not limited to, the following:
- Mechanisms of stem cell fate, lineage specification, and plasticity;
- Stem cell interactions with niche mechanisms and microenvironment;
- Stem cell models of developmental disorders and organogenesis;
- Stem cell-based interventions for neurodegeneration, musculoskeletal disease, and organ repair;
- Emerging technologies: Organoids, bioprinting, and engineered tissue platforms.
In this Special Issue, we aim to bring together pioneering work from across the spectrum of stem cell science—spanning fundamental biology to clinical translation. We warmly welcome original research articles, reviews, and perspectives that will enrich this Special Issue and shape future directions in the field.
Dr. Jerran Santos
Prof. Dr. Bruce Milthorpe
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- stem cell
- regeneration
- degenerative disorders
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