Exosomes and Nanomedicine Targeting β-Amyloid-Induced Neurotoxicity in Alzheimer’s Disease

Dear Colleagues,

β-Amyloid (Aβ) oligomers are major drivers of early synaptic dysfunction and impaired plasticity, Ca²⁺ overload, oxidative and ER stress, mitochondrial failure, and neuroinflammation, ultimately accelerating neuronal loss and cognitive decline in Alzheimer’s disease. Metabolic regulation—particularly AMPK and PPAR signaling—can reshape bioenergetics, lipid metabolism, and inflammatory tone, offering draggable leverage points. However, effective and safe delivery across the blood–brain barrier remains a central bottleneck for translation.

This Special Issue aims to unify molecular and translational advances in exosomes/extracellular vesicles (EVs) and nanomedicine that can prevent, diagnose, or reverse Aβ-induced neurotoxicity. We welcome studies on EV biogenesis and therapeutic cargo, engineered exosomes, nanoparticle and hybrid EV–nano delivery systems, BBB-penetrant targeting strategies, stimulus-responsive release, imaging and theragnostic platforms, and rigorous efficacy and safety evaluation in 2D/3D neuronal cultures, brain organoids, and in vivo models.

Dr. Ming-Chang Chiang
Guest Editor

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