Gene Regulation in Endocrine Disease, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 June 2026 | Viewed by 224
Special Issue Editor
Interests: osteoporosis; metabolic bone diseases; parathyroid diseases; multiple endocrine neoplasia; genetic diseases of bone
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gene regulation, a finely tuned process, governs the activation or repression of genes, ensuring a dynamic response to internal and external cues. Within the context of endocrine physiology, this regulation is particularly crucial, dictating the synthesis and secretion of hormones that exert systemic effects on diverse tissues and organs. The dysregulation of gene expression in the endocrine system can lead to a spectrum of diseases, ranging from subtle imbalances to overt pathological states.
Endocrine diseases, sporadic and inherited or heritable, encompass a broad spectrum of conditions, including diabetes mellitus, thyroid disorders, adrenal dysfunction, neuroendocrine tumors, and disorders of the reproductive system. In each case, the perturbation of gene regulation emerges as a critical player, influencing the synthesis, release, and responsiveness of hormones. The advent of advanced genomic technologies has empowered researchers to dissect the genetic basis of these diseases, paving the way for targeted therapeutic approaches and precision medicine.
The integration of molecular genetics and endocrinology has unveiled a rich tapestry of mechanisms through which gene regulation contributes to the development and progression of endocrine disorders. From mutations in transcription factors that modulate hormone synthesis to alterations in the regulatory regions of hormone-encoding genes, the genetic landscape of endocrine diseases is becoming increasingly better understood at the molecular level. Volume 1.0 of the Special Issue “Gene Regulation in Endocrine Disease” (https://www.mdpi.com/journal/ijms/special_issues/C75MXCPZ2P) has been highly successful. We therefore aim to reopen this topic as volume 2.0. This second Special Issue seeks to unravel the intricate interplay between gene regulation and endocrine diseases, offering insights into the molecular underpinnings that shape the pathophysiology of disorders within the endocrine system.
Dr. Alberto Falchetti
Guest Editor
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Keywords
- gene regulation
- endocrine disease
- endocrinology
- diabetes mellitus
- thyroid disorders
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