Advances in Pulp Biology and Pulp Repair
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 169
Special Issue Editor
Special Issue Information
Dear Colleagues,
The conventional paradigm of replacing diseased/inflamed pulp tissue with inert materials is being challenged by the advances in pulp biology and pulp repair, which are aimed at developing new treatment strategies. The better characterization of stem cell populations that are present in the dental pulp and their recruitment to the damaged tissue; the identification of new bioactive molecules, some of which are natural, with potent favorable cell signaling properties in the extracellular matrices of dentin and pulp, which can direct tissue events; and the development of strategies to elaborate on inflammatory events at the molecular level, are just some of the exciting advances in this field. As an example, with these breakthroughs, pulp-like constructs have already been developed in animals. However, it seems that many questions remain unsolved regarding the potential clinical translation of pulp regeneration (e.g., cell origin, odontoblast differentiation mechanisms, pulpal environment, the role of infection and inflammation, and pre-treatment of dentin to release fossilized signaling molecules). That being said, these questions provide an exciting platform of research from which the achievement translation of dental pulp regeneration can progress.
Best,
Prof. Dr. Tchilalo Boukpessi
Guest Editor
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Keywords
- pulp regeneration
- pulp capping
- pulpotomy
- vital pulp treatment
- stem cells
- tissue engineering
- scaffold
- bioactive molecules
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