ijms-logo

Journal Browser

Journal Browser

Metabolic Pathways in Cancer Cells

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 2524

Special Issue Editor


E-Mail Website
Guest Editor
Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy
Interests: tumor microenvironment; metabolism; cancer; metabolic reprogramming; Warburg effect; lactate
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic Pathways in Cancer Cells delves into the intricate relationship between cellular metabolism and cancer development, presenting a comprehensive exploration of the diverse metabolic alterations that occur in cancer cells. This Special Issue summarizes cutting-edge research, clarifying the key role of reprogramming metabolism in tumor cells, oncogenesis, tumor progression, and therapeutic resistance. Contributions include various aspects, including dysregulated glucose metabolism, aberrant lipid metabolism, and altered amino acid utilization, shedding light on the molecular mechanisms driving these metabolic changes. Furthermore, this Special Issue aims to explore the interplay between oncogenesis, signaling pathways, and metabolic adaptations, providing valuable insights into potential therapeutic targets. By promoting a deeper understanding of cancer metabolism, this Special Issue aims to catalyze the development of new diagnostic tools and therapeutic strategies to counteract cancer progression and improve patient outcomes.

Prof. Dr. Lucia Longhitano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tumor microenvironment
  • metabolism
  • cancer
  • metabolic reprogramming
  • Warburg effect
 

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

18 pages, 772 KiB  
Review
Metabolic Reprogramming of Immune Cells in the Tumor Microenvironment
by Jing Wang, Yuanli He, Feiming Hu, Chenchen Hu, Yuanjie Sun, Kun Yang and Shuya Yang
Int. J. Mol. Sci. 2024, 25(22), 12223; https://doi.org/10.3390/ijms252212223 - 14 Nov 2024
Cited by 1 | Viewed by 2132
Abstract
Metabolic reprogramming of immune cells within the tumor microenvironment (TME) plays a pivotal role in shaping tumor progression and responses to therapy. The intricate interplay between tumor cells and immune cells within this ecosystem influences their metabolic landscapes, thereby modulating the immune evasion [...] Read more.
Metabolic reprogramming of immune cells within the tumor microenvironment (TME) plays a pivotal role in shaping tumor progression and responses to therapy. The intricate interplay between tumor cells and immune cells within this ecosystem influences their metabolic landscapes, thereby modulating the immune evasion tactics employed by tumors and the efficacy of immunotherapeutic interventions. This review delves into the metabolic reprogramming that occurs in tumor cells and a spectrum of immune cells, including T cells, macrophages, dendritic cells, and myeloid-derived suppressor cells (MDSCs), within the TME. The metabolic shifts in these cell types span alterations in glucose, lipid, and amino acid metabolism. Such metabolic reconfigurations can profoundly influence immune cell function and the mechanisms by which tumors evade immune surveillance. Gaining a comprehensive understanding of the metabolic reprogramming of immune cells in the TME is essential for devising novel cancer therapeutic strategies. By targeting the metabolic states of immune cells, it is possible to augment their anti-tumor activities, presenting new opportunities for immunotherapeutic approaches. These strategies hold promise for enhancing treatment outcomes and circumventing the emergence of drug resistance. Full article
(This article belongs to the Special Issue Metabolic Pathways in Cancer Cells)
Show Figures

Figure 1

Back to TopTop