Epidemiology and Outcome of Invasive Fungal Disease in Children

Dear Colleagues,

This Special Issue is dedicated to the topic captured in its title, “Epidemiology and Outcomes of Invasive Fungal Disease (IFD) in Children”.

Invasive fungal infections, that result in IFD, are a heterogeneous group of yeast and mold infections which is still associated with significant morbidity and death in immunocompromised children. They are particularly relevant to children affected with hematologic malignancies, immunodeficiencies, hematopoietic stem cell transplant as well as solid organ transplant recipients, premature neonates, and debilitated children in pediatric intensive care units. Although considerable progress has recently been made in the prevention, diagnosis, and management of pediatric IFD, it continues to remain a challenge. Furthermore, the growing number of immunocompromised children at risk of IFD results in increased financial and organizational burden to the health care system.

The early detection of IFD is critical because therapeutic outcome strongly depends on the prompt initiation of appropriate interventions. Therefore, novel biomarkers measured in samples obtained noninvasively from children are highly desired. Furthermore, the development around the more beneficial imaging of mycotic lesions is also needed. The current antifungal prophylaxis, empiric, pre-emptive, and targeted therapy options for children are often supported by data from adults although children differ compared with them when it comes to IFD.

Research and review articles, large case series, and meta-analyses related to incidence, prevalence, and outcome of fungal infections in children treated for any reason are invited. Papers on the impact of prophylaxis, diagnostics, and treatment on outcomes are welcome as well.

Best regards,

Prof. Dr. Radosław Chaber
Guest Editor

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