Special Issue "Environmental and Occupational Exposure to Benzene and Oxidative Damage"
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Occupational Safety and Health".
Deadline for manuscript submissions: 30 April 2019
Prof. Giuseppe De Palma
University of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Section of Public Health and Human Sciences, Piazzale Spedali Civili, 1; 25123 Brescia, Italy
Interests: occupational and environmental toxicology of metals and organic solvents; occupational and environmental epidemiology; biological monitoring; risk assessment
Prof. Silvia Fustinoni
University of Milan, Department of Clinical Sciences and Community Health and Fondazione Ca’ Granda IRCCS Ospedale Maggiore Policlinico, Via San Barnaba 8, 20122 Milan, Italy
Interests: occupational and environmental toxicology of organic solvents, polycyclic aromatic hydrocarbons, pesticides; analytical chemistry applied to environmental toxicology; biological monitoring; risk assessment
The International Journal of Environmental Research and Public Health welcomes submissions for a Special Issue of the journal. This Special Issue will focus on environmental and occupational exposure to benzene and oxidative damage.
Benzene is still a chemical with public health concerns, due to its widespread use and its toxicological properties. It has been a long time since the compound was recognized as a human carcinogen, targeting, in particular, human bone marrow, but more recently other relevant health effects have been highlighted, in particular, the risk of male infertility and congenital anomalies.
In the context of environmental exposure to benzene, children are a particularly susceptible as potential targets.
A main toxicological mechanism through which benzene exerts its health effects is the induction of oxidative stress, which is linked, in particular, to its metabolism. Oxidative stress may cause multiple downstream consequences in different organs, including direct and indirect genetic damage and genetic dysregulation related to interference to epigenetic mechanisms.Prof. Giuseppe De Palma
Prof. Silvia Fustinoni
Manuscript Submission Information
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- oxidative stress
- DNA methylation