Next Article in Journal
Media Exposure and General Trust as Predictors of Post-traumatic Stress Disorder: Ten Years after the 5.12 Wenchuan Earthquake in China
Next Article in Special Issue
Effect of Benzene Exposure on the Urinary Biomarkers of Nucleic Acid Oxidation in Two Cohorts of Gasoline Pump Attendants
Previous Article in Journal
Phenanthrene Mitigates Cadmium Toxicity in Earthworms Eisenia fetida (Epigeic Specie) and Aporrectodea caliginosa (Endogeic Specie) in Soil
Previous Article in Special Issue
Epigenetic and Transcriptional Modifications in Repetitive Elements in Petrol Station Workers Exposed to Benzene and MTBE
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2018, 15(11), 2385; https://doi.org/10.3390/ijerph15112385

Gene Expression Response in Peripheral Blood Cells of Petroleum Workers Exposed to Sub-Ppm Benzene Levels

1
Department of Clinical Science, University of Bergen, P.O. Box 7804, N-5020 Bergen, Norway
2
Institute of Marine Research, P.O. Box 1870 Nordnes, N-5817 Bergen, Norway
3
Nofima AS, Osloveien 1, N-1430 Ås, Norway
4
Faculty of Science and Technology, Norwegian University of Life Sciences, NO-1430 Ås, Norway
5
Institute for Work and Health (IST), Universities of Lausanne and Geneva, CH-1066 Lausanne-Epalinges, Switzerland
6
Department of Medical Genetics, Haukeland University Hospital, P.O. Box 1400, N-5021 Bergen, Norway
7
Center for Cancer Biomarkers (CCBIO), Department of Clinical Science, Precision Oncology Research Group, University of Bergen, P.O. Box 7804, N-5020 Bergen, Norway
8
Department of Global Public Health and Primary Care, University of Bergen, P.O. Box 7804, N-5020 Bergen, Norway
*
Author to whom correspondence should be addressed.
Received: 31 July 2018 / Revised: 21 October 2018 / Accepted: 24 October 2018 / Published: 27 October 2018
Full-Text   |   PDF [1839 KB, uploaded 22 November 2018]   |  

Abstract

Altered gene expression in pathways relevant to leukaemogenesis, as well as reduced levels of circulating lymphocytes, have been reported in workers that were exposed to benzene concentrations below 1 ppm. In this study, we analysed whole blood global gene expression patterns in a worker cohort with altered levels of T cells and immunoglobulins IgM and IgA at three time points; pre-shift, post-shift (after three days), and post-recovery (12 hours later). Eight benzene exposed tank workers performing maintenance work in crude oil cargo tanks with a mean benzene exposure of 0.3 ppm (range 0.1–0.5 ppm) and five referents considered to be unexposed were examined by gene expression arrays. By using our data as independent validation, we reanalysed selected genes that were reported to be altered from previous studies of workers being exposed to sub-ppm benzene levels Four out of six genes previously proposed as marker genes in chronically exposed workers separated benzene exposed workers from unexposed referents (CLEC5, ACSL1, PRG2, IFNB1). Even better separation of benzene exposed workers and referents was observed for short-term exposure for genes in the Jak-STAT pathway, particularly elevated expression of IL6 and reduced expression of IL19. View Full-Text
Keywords: benzene; gene expression; inflammation; immune response; leukaemia risk; petroleum industry; offshore benzene; gene expression; inflammation; immune response; leukaemia risk; petroleum industry; offshore
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary materials

SciFeed

Share & Cite This Article

MDPI and ACS Style

Jørgensen, K.M.; Færgestad Mosleth, E.; Hovde Liland, K.; Hopf, N.B.; Holdhus, R.; Stavrum, A.-K.; Gjertsen, B.T.; Kirkeleit, J. Gene Expression Response in Peripheral Blood Cells of Petroleum Workers Exposed to Sub-Ppm Benzene Levels. Int. J. Environ. Res. Public Health 2018, 15, 2385.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top