Special Issue "The Exposome: State-of-the-Art and Future Perspectives"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Health".

Deadline for manuscript submissions: closed (31 December 2019).

Special Issue Editor

Prof. Dr. Elaine M. Faustman
Website
Guest Editor
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
Interests: characterizing variability in exposure across the lifecourse, children’s health, reproductive and developmental toxicity; integrative scientific approaches including identifying molecular mechanisms of developmental, reproductive, and neuro toxicants; characterizing in vitro techniques for toxicology assessment; developing biological and exposure-based dose-response models

Special Issue Information

Dear Colleagues,

The concept of the exposome embraces the complexity of real-life exposures, as we are not exposed to single chemicals but to mixtures that change over time. Incorporating exposomics into research has traditionally been limited by our ability to assess exposures. Novel techniques, such as targeted and untargeted exposure analysis, have vastly improved our ability to characterize exposures and provide the opportunity to dramatically improve our epidemiological and mechanistic research. However, challenges remain in the identification of agents and chemical evaluation in such analyses. New reference databases and biomonitoring efforts provide valuable tools for moving into the next phase of exposure analysis. Additionally, statistical methods for understanding the meaning of cumulative exposure and mixtures are becoming more readily available. This Special Issue invites articles related to the following:

  1. Novel techniques for assessing the exposome;
  2. Statistical methods for the interpretation of exposome data;
  3. Applications of the exposome for public health research and policy;
  4. Discussions of future directions of exposome research;
  5. Applications for precision medicine and for longitudinal disease trajectories.

Prof. Dr. Elaine M. Faustman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Exposome
  • Untargeted exposure assessment
  • Cumulative exposure assessment
  • Exposure mixtures
  • Metabolomics

Published Papers (2 papers)

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Open AccessArticle
Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort
Int. J. Environ. Res. Public Health 2020, 17(5), 1479; https://doi.org/10.3390/ijerph17051479 - 25 Feb 2020
Abstract
The exposome provides a conceptual model for identifying and characterizing lifetime environmental exposures and resultant health effects. In this study, we applied key exposome concepts to look specifically at the neurodevelopmental pesticide exposome, which focuses on exposures to pesticides that have the potential [...] Read more.
The exposome provides a conceptual model for identifying and characterizing lifetime environmental exposures and resultant health effects. In this study, we applied key exposome concepts to look specifically at the neurodevelopmental pesticide exposome, which focuses on exposures to pesticides that have the potential to cause an adverse neurodevelopmental impact. Using household dust samples from a children’s agricultural cohort located in the Yakima Valley of Washington state, we identified 87 individual pesticides using liquid chromatography-tandem mass spectrometry. A total of 47 of these have evidence of neurotoxicity included in the Environmental Protection Agency (EPA) (re)registration materials. We used a mixed effects model to model trends in pesticide exposure. Over the two study years (2005 and 2011), we demonstrate a significant decrease in the neurodevelopmental pesticide exposome across the cohort, but particularly among farmworker households. Additional analysis with a non-parametric binomial analysis that weighted the levels of potentially neurotoxic pesticides detected in household dust by their reference doses revealed that the decrease in potentially neurotoxic pesticides was largely a result of decreases in some of the most potent neurotoxicants. Overall, this study provides evidence that the neurodevelopmental pesticide exposome framework is a useful tool in assessing the effectiveness of specific interventions in reducing exposure as well as setting priorities for future targeted actions. Full article
(This article belongs to the Special Issue The Exposome: State-of-the-Art and Future Perspectives)
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Open AccessEssay
What Is New about the Exposome? Exploring Scientific Change in Contemporary Epidemiology
Int. J. Environ. Res. Public Health 2020, 17(8), 2879; https://doi.org/10.3390/ijerph17082879 - 22 Apr 2020
Abstract
In this commentary, I discuss the scientific changes brought by the exposome, asking what is new about this approach and line of research. I place the exposome in a historical perspective, by analyzing the conditions under which the exposome has been conceived, developed [...] Read more.
In this commentary, I discuss the scientific changes brought by the exposome, asking what is new about this approach and line of research. I place the exposome in a historical perspective, by analyzing the conditions under which the exposome has been conceived, developed and established in the context of contemporary epidemiological research. I argue that the exposome has been developed by transferring approaches, methods and conceptualizations from other lines of research in the life and health sciences. I thus discuss the conceptual and methodological innovations of the exposome as a result of the merging and adaptation of these elements for new uses and purposes. On this basis, I argue that the novelty of the exposome should be seen in incremental rather than revolutionary terms and, in this sense, the exposome shares significant elements with other projects and repertoires in postgenomics. I conclude by discussing the consequences of this analysis for the potential limitations and future development of exposome research. Full article
(This article belongs to the Special Issue The Exposome: State-of-the-Art and Future Perspectives)
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