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Healthcare
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Progress in Female Reproductive Health
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Progress in Female Reproductive Health

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Women’s and Children’s Health".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 1323

Special Issue Editors

Dr. Stefano Restaino

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Guest Editor
Department of Maternal and Child Health, University-Hospital of Udine, P.le S. Maria della Misericordia n° 15, 33100 Udine, Italy
Interests: gynecology; gynecology surgery; female healthcare; endometrial cancer; ovarian cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Martina Arcieri

E-Mail Website
Guest Editor
Department of Maternal and Child Health, “Santa Maria della Misericordia” University Hospital, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), 33100 Udine, Italy
Interests: gynecologic oncology; gynecological surgery; laparoscopic surgery; endometriosis; hysterectomy; screening; ovary
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Female reproductive health is a fundamental area of medicine with profound implications for individual well-being and public health. Despite notable progress in recent decades, many conditions—including infertility, endometriosis, gynecological cancers, pregnancy complications, and the influence of environmental and lifestyle factors—remain major clinical and research challenges.

Fertility-sparing strategies are increasingly integrated into routine gynecologic and oncologic practice, influencing patient counseling, shared decision making, and long-term quality of life. Their impact extends beyond clinical outcomes, touching on psychosocial well-being, family planning, and the patient’s sense of autonomy during and after treatment. This Special Issue, “Progress in Female Reproductive Health”, highlights recent developments in basic, translational, and clinical research aimed at enhancing diagnostic accuracy, advancing therapeutic strategies, and strengthening preventive approaches in this field. Key topics include the clinical application of novel biomarkers, innovations in reproductive care, fertility preservation, maternal–fetal health, and the integration of genetics, epigenetics, and precision medicine into patient management.    

By bringing together contributions from diverse disciplines, this collection underscores the importance of multidisciplinary collaboration in expanding knowledge and improving clinical outcomes for women worldwide. We anticipate that the articles included in this Special Issue will serve as a valuable resource for clinicians, researchers, and policymakers, while stimulating further investigation to address the unmet needs in female reproductive health.

Dr. Stefano Restaino
Dr. Martina Arcieri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis
  • endometrial cancer
  • fertility
  • obstetrics
  • maternal fetal health

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Published Papers (1 paper)

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16 pages, 1599 KB  
Case Report
Late Cervical Recurrence of Invasive Lobular Carcinoma Ten Years After Primary Breast Cancer: A Case Report and Review of the Literature
by Giulia Pellecchia, Stefano Restaino, Matteo Alfarè Lovo, Martina Arcieri, Monica Della Martina, Marco Petrillo, Giampiero Capobianco, Lorenza Driul, Giuseppe Vizzielli and The Gynecological Oncological Tumor Board Group
Healthcare 2026, 14(2), 201; https://doi.org/10.3390/healthcare14020201 - 13 Jan 2026
Viewed by 958
Abstract
Invasive lobular carcinoma (ILC) accounts for approximately 15% of breast cancers and the most common neoplasm in the female population. Cervical involvement is exceptionally rare and often underrecognized. This relationship is well-defined in the context of breast and ovarian cancer syndrome related to [...] Read more.
Invasive lobular carcinoma (ILC) accounts for approximately 15% of breast cancers and the most common neoplasm in the female population. Cervical involvement is exceptionally rare and often underrecognized. This relationship is well-defined in the context of breast and ovarian cancer syndrome related to BRCA gene mutations. However, it is also observed in rare but underreported cases of cervical metastases originating from breast cancer. The objective of this manuscript is to describe a rare case of cervical recurrence of invasive lobular carcinoma and summarize comparable case to guide future gynecologic follow-up strategies. Therefore, we report the case of a 60-year-old woman who developed a late cervical recurrence of ILC ten years after her initial breast cancer diagnosis. The patient had previously undergone mastectomy for ER-positive, PR-positive, HER2-negative ILC, followed by five years of adjuvant endocrine therapy. She remained disease-free until presenting with post-menopausal bleeding, urinary symptoms, and acute renal failure. Pelvic examination and ultrasonography revealed an enlarged, indurated cervix with bilateral hydroureteronephrosis. Biopsy demonstrated a discohesive infiltrate consistent with metastatic lobular carcinoma, confirmed by immunohistochemistry (GATA3+, CK7+, ER/PR+, E-cadherin−, CK20−, CDX2−). Staging PET-CT showed additional metastases involving bone, peritoneum, and lymph nodes. The patient began systemic therapy with ribociclib plus letrozole, achieving radiologic improvement of the cervical lesion and abdominal disease. After a follow-up of several months, she maintains stable disease but has persistent chronic renal impairment secondary to obstructive uropathy. This case highlights the ability of ILC to recur after long latency and to metastasize to unusual gynecologic sites such as the cervix. We also review the literature on cervical recurrence from lobular carcinoma to emphasize the importance of gynecologic surveillance in breast cancer survivors and to identify areas that require further investigation. Full article
(This article belongs to the Special Issue Progress in Female Reproductive Health)
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