Late Cervical Recurrence of Invasive Lobular Carcinoma Ten Years After Primary Breast Cancer: A Case Report and Review of the Literature

Pellecchia, Giulia; Restaino, Stefano; Alfarè Lovo, Matteo; Arcieri, Martina; Della Martina, Monica; Petrillo, Marco; Capobianco, Giampiero; Driul, Lorenza; Vizzielli, Giuseppe; The Gynecological Oncological Tumor Board Group,

doi:10.3390/healthcare14020201

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Late Cervical Recurrence of Invasive Lobular Carcinoma Ten Years After Primary Breast Cancer: A Case Report and Review of the Literature

by

Giulia Pellecchia

^1,2,†

,

Stefano Restaino

^2,3,*,†

,

Matteo Alfarè Lovo

^1,2

,

Martina Arcieri

²

,

Monica Della Martina

²,

Marco Petrillo

⁴

,

Giampiero Capobianco

⁴

,

Lorenza Driul

^1,2

,

Giuseppe Vizzielli

^1,2

and

The Gynecological Oncological Tumor Board Group

^{1,5,6,7,8,9,10,11,12,‡}

¹

Department of Medicine, University of Udine, 33100 Udine, Italy

²

Clinic of Obstetrics and Gynecology, “Santa Maria della Misericordia” University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy

³

PhD School in Biomedical Sciences, Gender Medicine, Child and Women Health, University of Sassari, 07100 Sassari, Italy

⁴

Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy

⁵

Institute of Pathology, “Santa Maria della Misericordia” University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy

⁶

Department of Medical Oncology, “S. Maria della Misericordia” University Hospital, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), 33100 Udine, Italy

⁷

Department of Oncological Radiotherapy, S.M. della Misericordia University Hospital, University of Udine, 33100 Udine, Italy

⁸

Department of Obstetrics and Gynecology, Center for Fetal Care and High-Risk Pregnancy, University of Chieti, 66100 Chieti, Italy

⁹

Department of Human Pathology in Adult and Childhood “G. Barresi”, University of Messina, 98125 Messina, Italy

¹⁰

Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

¹¹

Department of Medical and Surgical Sciences, Institute of Obstetrics and Gynaecology, University of Foggia, 71122 Foggia, Italy

¹²

Department of Medicine, Surgery and Health Sciences, University of Trieste, 34149 Trieste, Italy

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^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

^‡

Authors of the group are provided in the Acknowledgements.

Healthcare 2026, 14(2), 201; https://doi.org/10.3390/healthcare14020201

Submission received: 29 October 2025 / Revised: 30 December 2025 / Accepted: 8 January 2026 / Published: 13 January 2026

(This article belongs to the Special Issue Progress in Female Reproductive Health)

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Abstract

Invasive lobular carcinoma (ILC) accounts for approximately 15% of breast cancers and the most common neoplasm in the female population. Cervical involvement is exceptionally rare and often underrecognized. This relationship is well-defined in the context of breast and ovarian cancer syndrome related to BRCA gene mutations. However, it is also observed in rare but underreported cases of cervical metastases originating from breast cancer. The objective of this manuscript is to describe a rare case of cervical recurrence of invasive lobular carcinoma and summarize comparable case to guide future gynecologic follow-up strategies. Therefore, we report the case of a 60-year-old woman who developed a late cervical recurrence of ILC ten years after her initial breast cancer diagnosis. The patient had previously undergone mastectomy for ER-positive, PR-positive, HER2-negative ILC, followed by five years of adjuvant endocrine therapy. She remained disease-free until presenting with post-menopausal bleeding, urinary symptoms, and acute renal failure. Pelvic examination and ultrasonography revealed an enlarged, indurated cervix with bilateral hydroureteronephrosis. Biopsy demonstrated a discohesive infiltrate consistent with metastatic lobular carcinoma, confirmed by immunohistochemistry (GATA3+, CK7+, ER/PR+, E-cadherin−, CK20−, CDX2−). Staging PET-CT showed additional metastases involving bone, peritoneum, and lymph nodes. The patient began systemic therapy with ribociclib plus letrozole, achieving radiologic improvement of the cervical lesion and abdominal disease. After a follow-up of several months, she maintains stable disease but has persistent chronic renal impairment secondary to obstructive uropathy. This case highlights the ability of ILC to recur after long latency and to metastasize to unusual gynecologic sites such as the cervix. We also review the literature on cervical recurrence from lobular carcinoma to emphasize the importance of gynecologic surveillance in breast cancer survivors and to identify areas that require further investigation.

Keywords: breast cancer; recurrence; uterine cervical neoplasm; lobular carcinoma; case report; review literature

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MDPI and ACS Style

Pellecchia, G.; Restaino, S.; Alfarè Lovo, M.; Arcieri, M.; Della Martina, M.; Petrillo, M.; Capobianco, G.; Driul, L.; Vizzielli, G.; The Gynecological Oncological Tumor Board Group. Late Cervical Recurrence of Invasive Lobular Carcinoma Ten Years After Primary Breast Cancer: A Case Report and Review of the Literature. Healthcare 2026, 14, 201. https://doi.org/10.3390/healthcare14020201

AMA Style

Pellecchia G, Restaino S, Alfarè Lovo M, Arcieri M, Della Martina M, Petrillo M, Capobianco G, Driul L, Vizzielli G, The Gynecological Oncological Tumor Board Group. Late Cervical Recurrence of Invasive Lobular Carcinoma Ten Years After Primary Breast Cancer: A Case Report and Review of the Literature. Healthcare. 2026; 14(2):201. https://doi.org/10.3390/healthcare14020201

Chicago/Turabian Style

Pellecchia, Giulia, Stefano Restaino, Matteo Alfarè Lovo, Martina Arcieri, Monica Della Martina, Marco Petrillo, Giampiero Capobianco, Lorenza Driul, Giuseppe Vizzielli, and The Gynecological Oncological Tumor Board Group. 2026. "Late Cervical Recurrence of Invasive Lobular Carcinoma Ten Years After Primary Breast Cancer: A Case Report and Review of the Literature" Healthcare 14, no. 2: 201. https://doi.org/10.3390/healthcare14020201

APA Style

Pellecchia, G., Restaino, S., Alfarè Lovo, M., Arcieri, M., Della Martina, M., Petrillo, M., Capobianco, G., Driul, L., Vizzielli, G., & The Gynecological Oncological Tumor Board Group. (2026). Late Cervical Recurrence of Invasive Lobular Carcinoma Ten Years After Primary Breast Cancer: A Case Report and Review of the Literature. Healthcare, 14(2), 201. https://doi.org/10.3390/healthcare14020201

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Late Cervical Recurrence of Invasive Lobular Carcinoma Ten Years After Primary Breast Cancer: A Case Report and Review of the Literature

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