Special Issue "Mitochondria and Aging"
Deadline for manuscript submissions: closed (31 October 2017).
Interests: basic biology of aging; dynamics of intracellular mitochondrial population; nuclear pseudogenes of mtDNA - NUMTs; human evolution; somatic mitochondrial DNA mutations, their abundance and relevance to human aging and disease
Aging is a remarkably complex phenomenon. Some of us believe that this complexity is no coincidence, that evolution of longevity inevitably drives the aging process to be complex and redundant. We only start to appreciate this complexity.
The Mitochondrial Theory of Aging gives an example of this trend. The Theory has emerged from Dedham Harman’s idea that mitochondrial reactive oxygen species are the primary driver of aging. Today we appreciate that, first, ROS are not necessarily bad and may actually have ameliorating effect on the aging organism, e.g., during exercise. Second, detrimental processes in the mitochondria are not necessarily related to ROS production, e.g., clonally accumulating somatic mtDNA mutations that merely impede mitochondrial respiration. In fact, at present there are several independent theories relating processes in mitochondria to aging. The apparent complexity of aging implies that these theories need not be competitors, contending for the title of “the Correct Theory of Aging”. I fact many of them may be equally correct and reflect the different facets of the aging process.
In this Special Issue, we welcome reviews, new methods, and original articles covering many possible roles the mitochondria may play in the aging process. We look forward to your contributions.
Prof. Dr. Konstantin Khrapko
Prof. Dr. Dori Woods
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- mitochondrial dysfunction
- mitochondrial theory of aging
- energetics and aging
- oxidative damage
- oxidative stress
- protein turnover
- mitochondrial dynamics
- aging of the germ line
- lipid peroxidation
- evolution of aging
- Alzheimer disease
- Parkinson disease