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Genes 2018, 9(4), 182; https://doi.org/10.3390/genes9040182

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

1
Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
2
LLHW Centre for Aging and Vitality, Newcastle University Institute for Aging, The Medical School, Newcastle upon Tyne NE2 4HH, UK
*
Author to whom correspondence should be addressed.
Received: 26 February 2018 / Revised: 22 March 2018 / Accepted: 26 March 2018 / Published: 27 March 2018
(This article belongs to the Special Issue Mitochondria and Aging)
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Abstract

Mitochondrial DNA (mtDNA) mutations accumulate in somatic stem cells during ageing and cause mitochondrial dysfunction. In this review, we summarize the studies that link mtDNA mutations to stem cell ageing. We discuss the age-related behaviours of the somatic mtDNA mutations in stem cell populations and how they potentially contribute to stem cell ageing by altering mitochondrial properties in humans and in mtDNA-mutator mice. We also draw attention to the diverse fates of the mtDNA mutations with different origins during ageing, with potential selective pressures on the germline inherited but not the somatic mtDNA mutations. View Full-Text
Keywords: stem cell; mitochondrial DNA mutation; ageing; purifying selection; mitochondrial mutagenesis; progenitor; mitochondrial disease; ageing mouse model; mitochondrial DNA-mutator mouse; mitochondria stem cell; mitochondrial DNA mutation; ageing; purifying selection; mitochondrial mutagenesis; progenitor; mitochondrial disease; ageing mouse model; mitochondrial DNA-mutator mouse; mitochondria
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Su, T.; Turnbull, D.M.; Greaves, L.C. Roles of Mitochondrial DNA Mutations in Stem Cell Ageing. Genes 2018, 9, 182.

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