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The Mitochondrial Basis of Aging and Age-Related Disorders
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Genes 2018, 9(1), 22; https://doi.org/10.3390/genes9010022

The Aging Mitochondria

1,* and 1,2,*
1
Department of Biomedical Sciences, University of Padova, Padova 35121, Italy
2
Neuroscience Institute, National Research Council (CNR), Padova 35121, Italy
*
Authors to whom correspondence should be addressed.
Received: 26 October 2017 / Revised: 15 December 2017 / Accepted: 4 January 2018 / Published: 9 January 2018
(This article belongs to the Special Issue Mitochondria and Aging)
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Abstract

Mitochondrial dysfunction is a central event in many pathologies and contributes as well to age-related processes. However, distinguishing between primary mitochondrial dysfunction driving aging and a secondary mitochondrial impairment resulting from other cell alterations remains challenging. Indeed, even though mitochondria undeniably play a crucial role in aging pathways at the cellular and organismal level, the original hypothesis in which mitochondrial dysfunction and production of free radicals represent the main driving force of cell degeneration has been strongly challenged. In this review, we will first describe mitochondrial dysfunctions observed in aged tissue, and how these features have been linked to mitochondrial reactive oxygen species (ROS)–mediated cell damage and mitochondrial DNA (mtDNA) mutations. We will also discuss the clues that led to consider mitochondria as the starting point in the aging process, and how recent research has showed that the mitochondria aging axis represents instead a more complex and multifactorial signaling pathway. New working hypothesis will be also presented in which mitochondria are considered at the center of a complex web of cell dysfunctions that eventually leads to cell senescence and death. View Full-Text
Keywords: aging; mitochondria; ROS; MFRTA; mitochondrial function; mtDNA mutations; mutator mouse; lifespan aging; mitochondria; ROS; MFRTA; mitochondrial function; mtDNA mutations; mutator mouse; lifespan
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Theurey, P.; Pizzo, P. The Aging Mitochondria. Genes 2018, 9, 22.

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