Special Issue "Genetics of Alzheimer's Disease: The Role of Polygenic and Epistasis Components"
Deadline for manuscript submissions: 15 October 2021.
2. Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Interests: clinical neurology; neuropathology and experimental neurobiology; rare neurological and neuromuscular diseases; neurogenetics; nutraceuticals; nanotechnologies and functional foods; neurodegenerative disorders; autophagy
Special Issues and Collections in MDPI journals
Alzheimer’s disease (AD) is the most common neurodegenerative disease, but its causes remain largely unclear. Genetic risk variants identified so far show either small effect sizes or with larger effects but are extremely rare in frequency among the population. AD’s missing heritability remains therefore extensive, which has been attributed, at least partially, to mechanisms not currently investigated by traditional “single-locus” approaches, i.e., testing a single genetic variant and/or gene. In this Special Issue, we will focus on “multi-locus” approaches, i.e., the role of polygenic risk scores (PRS, i.e., the summation of multiple risk loci across the genome) and epistasis (i.e., interaction between genetic loci) in the context of AD and its endophenotypes.
Prof. Dr. Mariarosa Anna Beatrice Melone
Dr. Giuseppe Tosto
Manuscript Submission Information
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- Alzheimer’s disease
- Polygenic risk score