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Genes
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Psychiatric and Behavioral Genetics
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Psychiatric and Behavioral Genetics

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 29261

Special Issue Editor

Prof. Dr. Zhiqiang Li

E-Mail Website
Guest Editor
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China
Interests: schizophrenia; genome-wide association study; regulatory variants; mendelian randomization; genetic correlation

Special Issue Information

Dear Colleagues,

We would like to invite you to participate in this Special Issue, “Psychiatric and Behavioral Genetics”.

A large number of psychiatric and behavioral disorders affecting children (i.e., autism spectrum disorder) and/or adults (i.e., schizophrenia) have been identified. The prevalence of these disorders has been increasing during recent decades. Understanding the underlying pathogeneses that lead to psychiatric and behavioral disorders is important for preventive and mitigative efforts. However, the highly heterogeneous nature of psychiatric and behavioral disorders poses great challenges in elucidating pathogenies and investigating the pathogenesis. Recent researchers have suggested that a combination of genetic and environmental factors may determine the etiology of most disorders. Therefore, identification of these key factors, particularly the association between genetic and environmental risk factors, would be of great benefit to the diagnosis and treatment of these illnesses in clinical environments.

We encourage submissions of unpublished original manuscripts (research articles, reviews, and communications) focusing on the emerging molecular mechanisms of the genetic and/or epigenetic regulation of the onset and progression of psychiatric and behavioral disorders with various model systems. We also welcome the submission of studies related to potential therapeutic strategies for psychiatric and behavioral disorders.

Prof. Dr. Zhiqiang Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epigenetic regulation
  • microRNA
  • autism spectrum disorder
  • schizophrenia
  • neural stem cells

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Review

19 pages, 1127 KiB  
Review
Review of Personalized Medicine and Pharmacogenomics of Anti-Cancer Compounds and Natural Products
by Yalan Zhou, Siqi Peng, Huizhen Wang, Xinyin Cai and Qingzhong Wang
Genes 2024, 15(4), 468; https://doi.org/10.3390/genes15040468 - 8 Apr 2024
Cited by 11 | Viewed by 8730
Abstract
In recent years, the FDA has approved numerous anti-cancer drugs that are mutation-based for clinical use. These drugs have improved the precision of treatment and reduced adverse effects and side effects. Personalized therapy is a prominent and hot topic of current medicine and [...] Read more.
In recent years, the FDA has approved numerous anti-cancer drugs that are mutation-based for clinical use. These drugs have improved the precision of treatment and reduced adverse effects and side effects. Personalized therapy is a prominent and hot topic of current medicine and also represents the future direction of development. With the continuous advancements in gene sequencing and high-throughput screening, research and development strategies for personalized clinical drugs have developed rapidly. This review elaborates the recent personalized treatment strategies, which include artificial intelligence, multi-omics analysis, chemical proteomics, and computation-aided drug design. These technologies rely on the molecular classification of diseases, the global signaling network within organisms, and new models for all targets, which significantly support the development of personalized medicine. Meanwhile, we summarize chemical drugs, such as lorlatinib, osimertinib, and other natural products, that deliver personalized therapeutic effects based on genetic mutations. This review also highlights potential challenges in interpreting genetic mutations and combining drugs, while providing new ideas for the development of personalized medicine and pharmacogenomics in cancer study. Full article
(This article belongs to the Special Issue Psychiatric and Behavioral Genetics)
21 pages, 519 KiB  
Review
Association of Single Nucleotide Polymorphisms of Cytokine Genes with Depression, Schizophrenia and Bipolar Disorder
by Ekaterina V. Mikhalitskaya, Natalya M. Vyalova, Evgeny A. Ermakov, Lyudmila A. Levchuk, German G. Simutkin, Nikolay A. Bokhan and Svetlana A. Ivanova
Genes 2023, 14(7), 1460; https://doi.org/10.3390/genes14071460 - 17 Jul 2023
Cited by 13 | Viewed by 5390
Abstract
Immune gene variants are known to be associated with the risk of psychiatric disorders, their clinical manifestations, and their response to therapy. This narrative review summarizes the current literature over the past decade on the association of polymorphic variants of cytokine genes with [...] Read more.
Immune gene variants are known to be associated with the risk of psychiatric disorders, their clinical manifestations, and their response to therapy. This narrative review summarizes the current literature over the past decade on the association of polymorphic variants of cytokine genes with risk, severity, and response to treatment for severe mental disorders such as bipolar disorder, depression, and schizophrenia. A search of literature in databases was carried out using keywords related to depressive disorder, bipolar disorder, schizophrenia, inflammation, and cytokines. Gene lists were extracted from publications to identify common genes and pathways for these mental disorders. Associations between polymorphic variants of the IL1B, IL6, and TNFA genes were the most replicated and relevant in depression. Polymorphic variants of the IL1B, IL6, IL6R, IL10, IL17A, and TNFA genes have been associated with schizophrenia. Bipolar disorder has mainly been associated with polymorphic variants of the IL1B gene. Interestingly, the IL6R gene polymorphism (rs2228145) was associated with all three diseases. Some cytokine genes have also been associated with clinical presentation and response to pharmacotherapy. There is also evidence that some specific polymorphic variants may affect the expression of cytokine genes. Thus, the data from this review indicate a link between neuroinflammation and severe mental disorders. Full article
(This article belongs to the Special Issue Psychiatric and Behavioral Genetics)
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15 pages, 850 KiB  
Review
Folate–Methionine Cycle Disruptions in ASD Patients and Possible Interventions: A Systematic Review
by Melissa Roufael, Tania Bitar, Yonna Sacre, Christian Andres and Walid Hleihel
Genes 2023, 14(3), 709; https://doi.org/10.3390/genes14030709 - 13 Mar 2023
Cited by 13 | Viewed by 14510
Abstract
Autism Spectrum Disorder (ASD) has become a major public health concern due to its rapidly rising incidence over the past few years. Disturbances in folate or methionine metabolism have been identified in many individuals with ASD, suggesting that the folate–methionine cycle may play [...] Read more.
Autism Spectrum Disorder (ASD) has become a major public health concern due to its rapidly rising incidence over the past few years. Disturbances in folate or methionine metabolism have been identified in many individuals with ASD, suggesting that the folate–methionine cycle may play an essential role in the pathogenesis of autism. Thus, changes in metabolite concentrations associated with this cycle could be used as potential biomarkers and therapeutic targets for ASD. The aim of this systematic review is to elucidate the perturbations of this cycle and the possible interventions that may be proposed in this context. Several studies have shown that high levels of homocysteine and low levels of vitamins B12 and folate are associated with ASD. These changes in serum metabolites are influenced by poor diet. In fact, children with ASD tend to eat selectively, which could compromise the quality of their diet and result in nutrient deficiencies. Moreover, these disturbances may also be caused by genetic predispositions such as polymorphisms of the MTHFR gene. Few studies have demonstrated the beneficial effects of the use of nutritional supplements in treating ASD children. Therefore, larger, well-structured studies are recommended to examine the impact of vitamin B12 and folate supplementation on homocysteine levels. Full article
(This article belongs to the Special Issue Psychiatric and Behavioral Genetics)
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