Design of Supramolecular Hydrogels (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Analysis and Characterization".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 757

Special Issue Editors


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Guest Editor
Department of Chemistry, Science Institute, University of Iceland, Dunhagi 3, 107 Reykjavík, Iceland
Interests: supramolecular gel; peptide hydrogel; metallogel; X-ray crystallography; antibacterial activity
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Guest Editor
School of Chemistry, Joseph Banks Laboratories, University of Lincoln, Lincoln LN6 7TS, UK
Interests: supramolecular chemistry
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Guest Editor
Department of Chemistry, University of Jyvaskyla, 40014 Jyväskylä, Finland
Interests: bio-organic supramolecular chemistry; NMR spectroscopy
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Special Issue Information

Dear Colleagues,

Supramolecular hydrogels, a fascinating class of soft materials, have gained significant attention in recent years due to their wide-ranging applications in fields such as drug delivery, tissue engineering, and environmental remediation. This Special Issue entitled "Design of Supramolecular Hydrogels (2nd Edition)" aims to provide a comprehensive platform for researchers to showcase their innovative work and insights into the development and applications of supramolecular hydrogels.

The aim of this Special Issue is to explore various aspects of supramolecular hydrogel design, including the rational design of molecular building blocks, predicting gel-state properties, the incorporation of functional elements, and the optimization of gelation processes. We encourage the submission of contributions presenting the characterization of these hydrogels, their mechanical properties, the elucidation of their unique self-assembly mechanisms, and the exploration of potential applications in diverse fields.

Authors are invited to submit research articles, reviews, and perspectives that address challenges and advancements in supramolecular hydrogel design, from fundamental principles to practical applications. The submission of both theoretical and experimental studies is welcome. By fostering a deeper understanding of these materials, this Special Issue aims to accelerate progress in the field and inspire innovative approaches for designing supramolecular hydrogels with enhanced properties and broader utility. Researchers from diverse disciplines are encouraged to participate in this interdisciplinary exploration and strengthen collaboration and knowledge exchange in this exciting area of research.

Dr. Dipankar Ghosh
Dr. Gareth O. Lloyd
Dr. Elina I. Sievanen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • designing new supramolecular hydrogelators
  • prediction of gel properties
  • mechanism of self-assembly
  • hydrogel characterization
  • structure–property relationship
  • applications in diverse fields
  • smart hydrogels
  • 3D/4D printing
  • tissue engineering
  • regenerative medicine
  • controlled release systems
  • biodegradable hydrogels

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Published Papers (1 paper)

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18 pages, 7018 KB  
Article
Effect of pH on the Emergent Viscoelastic Properties of Cationic Phenylalanine-Derived Supramolecular Hydrogels
by Pamela Agredo, Shruti Ghosh, Brittany L. Abraham and Bradley L. Nilsson
Gels 2025, 11(11), 877; https://doi.org/10.3390/gels11110877 - 1 Nov 2025
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Abstract
Supramolecular hydrogels formed by the self-assembly of low-molecular-weight (LMW) agents are promising next-generation biomaterials for drug delivery, tissue engineering, and regenerative medicine. Phenylalanine (Phe) derivatives have emerged as a privileged class of LMW supramolecular gelators due to their strong propensity to self-assemble into [...] Read more.
Supramolecular hydrogels formed by the self-assembly of low-molecular-weight (LMW) agents are promising next-generation biomaterials for drug delivery, tissue engineering, and regenerative medicine. Phenylalanine (Phe) derivatives have emerged as a privileged class of LMW supramolecular gelators due to their strong propensity to self-assemble into emergent hydrogel networks with demonstrated biocompatibility. We have previously reported a series of cationic Phe-derived gelators in which fluorenylmethoxycarbonyl (Fmoc) phenylalanine (Phe), 3-fluorophenylalanine (3F-Phe), and pentafluorophenylalanine (F5-Phe) are functionalized at the C-terminus with diaminopropane (DAP). These gelators (Fmoc-Phe-DAP, Fmoc-3F-Phe-DAP, and Fmoc-F5-Phe-DAP) are water-soluble and undergo spontaneous self-assembly and gelation upon an increase in the ionic strength of the solution caused by addition of sodium chloride. Herein, we report the effects of pH on the self-assembly and gelation of Fmoc-Phe-DAP, Fmoc-3F-Phe-DAP, and Fmoc-F5-Phe-DAP. We also describe the effects that pH has on the emergent properties of these hydrogel networks, including assembly morphology and hydrogel viscoelasticity. These studies indicate that pH has varying effects on the properties of the hydrogels that are also dependent on the molecular structure of the Fmoc-Phe-DAP derivative. Fmoc-Phe-DAP hydrogels are highly sensitive to changes in solvent pH, forming strong hydrogels only near neutral pH. In contrast, hydrogels of Phe derivatives with fluorinated side chains (Fmoc-3F-Phe-DAP and Fmoc-F5-Phe-DAP) have consistent emergent viscoelastic properties across a wider range of acidic to basic pH values. Full article
(This article belongs to the Special Issue Design of Supramolecular Hydrogels (2nd Edition))
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