Advances in Hydrogels for 3D Printing

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Processing and Engineering".

Deadline for manuscript submissions: closed (15 September 2024) | Viewed by 1664

Special Issue Editors


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Guest Editor
Functional Nanomaterials, Department of Material Science, Faculty of Engineering, Kiel University, 24143 Kiel, Germany
Interests: polymer characterization; 3D printing; polymers; nanomaterials; polymer engineering; biopolymers; hydrogels

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Guest Editor
Institute of Materials Science, Faculty of Engineering, Kiel University, 24143 Kiel, Germany
Interests: bio-inspired materials; biosensors; biomedical engineering; molecularly imprinted polymers; molecular modelling; encapsulation; bioactive compounds
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Special Issue Information

Dear Colleagues,

Hydrogels are soft polymeric solids with high water content, known for their porous structure and high tuneability. Typically, they are built-up of long chains of synthetic or natural polymers which are then crosslinked to each other. This forms an inseparable network capable of high diffusion and high capacity. The possibility to incorporate natural or synthetic molecules, nano- and microparticles, to functionalize and tailor their properties makes them excellent platforms for applications in medicine or energy-related questions. Additive manufacturing as a 3D-shaping method provides a suitable process to capitalize on the advantages of hydrogels. There are numerous methods for additive manufacturing such as extrusion-based techniques or inkjet printing. For instance, larger channels can be incorporated within the hydrogels to use them as capacitor electrolytes, cell templates or filters.

This Special Issue aims to collate research papers that highlight the remarkable capabilities of 3D-printed hydrogels and the advantages that additively manufactured hydrogels possess, particularly focusing on their applications in the fields of medicine and energy.

Dr. Leonard Siebert
Prof. Dr. Zeynep Altintas
Guest Editors

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Keywords

  • hydrogels
  • 3D printing
  • templates
  • functionalization
  • nanomaterials

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Published Papers (1 paper)

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Research

24 pages, 19333 KiB  
Article
Development of Thermosensitive Hydrogels with Tailor-Made Geometries to Modulate Cell Harvesting of Non-Flat Cell Cultures
by Rubén García-Sobrino, Enrique Martínez-Campos, Daniel Marcos-Ríos, Zenen Zepeda-Rodríguez, Juan L. Valentín, Raúl Sanz-Horta, Marina León-Calero, Helmut Reinecke, Carlos Elvira, Alberto Gallardo and Juan Rodríguez-Hernández
Gels 2024, 10(12), 802; https://doi.org/10.3390/gels10120802 - 6 Dec 2024
Cited by 1 | Viewed by 1057
Abstract
Considering the complexity in terms of design that characterizes the different tissues of the human body, it is necessary to study and develop more precise therapies. In this sense, this article presents the possibility of fabricating photocurable thermosensitive hydrogels with free geometry and [...] Read more.
Considering the complexity in terms of design that characterizes the different tissues of the human body, it is necessary to study and develop more precise therapies. In this sense, this article presents the possibility of fabricating photocurable thermosensitive hydrogels with free geometry and based on N-Vinyl Caprolactam (VCL) with the aim of modulating the adhesion of non-planar cell cultures. The fabrication process is based on the use as a mold of two-layer thick water-soluble polyvinyl alcohol (PVA) previously printed by Extrusion Material (MatEx). From this technology it has been possible to obtain hydrogels with different 3D geometries and different crosslinking percentages (2, 4 and 6 mol%). Studies have shown that networks reduce their thermosensitivity not only when the percentage of crosslinking in the formulation increases, but also when the thickness of the hydrogel obtained increases. Based on this reduction in thermosensitivity, the less crosslinked (2 mol%) hydrogels have been evaluated to carry out a novel direct application in which hydrogels with curved geometry have allowed cell adhesion and proliferation at 37 °C with the endothelial cell line C166-GFP; likewise, non-aggressive cell detachment was observed when the hydrogel temperature was reduced to values of 20 °C. Therefore, the present manuscript shows a novel application for the synthesis of free-form thermosensitive hydrogels that allows modulation of non-planar cell cultures. Full article
(This article belongs to the Special Issue Advances in Hydrogels for 3D Printing)
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