Revolutionizing Medical Image Analysis with Deep Learning, 2nd Edition

A special issue of Electronics (ISSN 2079-9292). This special issue belongs to the section "Computer Science & Engineering".

Deadline for manuscript submissions: closed (15 April 2025) | Viewed by 2907

Special Issue Editors


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Guest Editor
Department of Software Engineering, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek, Osijek 31000, Croatia
Interests: image processing; computer vision; deep learning; machine learning; medical image processing and analysis; visual computing
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Software Engineering, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek, Osijek 31000, Croatia
Interests: image compression; image processing; computer vision; machine learning; medical image processing and analysis; visual computing
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Faculty of Mechanical Engineering, Computing and Electrical Engineering, University of Mostar, Mostar, Bosnia and Herzegovina
Interests: image processing; computer vision; deep learning; machine learning; visual computing

E-Mail Website
Guest Editor
Faculty of Mechanical Engineering, Computing and Electrical Engineering, University of Mostar, Mostar, Bosnia and Herzegovina
Interests: image processing; computer vision; deep learning; machine learning; visual computing

Special Issue Information

Dear Colleagues,

This Special Issue of the MDPI journal Electronics, titled "Revolutionizing Medical Image Analysis with Deep Learning", focuses on the growing trend in using deep learning algorithms in the field of medical imaging. Medical imaging is an essential component in the diagnosis, treatment, and monitoring of various diseases and conditions, and deep learning has the potential to significantly improve the accuracy, efficiency, and reliability of medical image analysis.

In addition to deep learning, the integration of Explainable Artificial Intelligence (XAI) is emerging as a critical area of focus. XAI aims to make the decision-making processes of complex deep learning models more transparent and interpretable, which is particularly crucial in the sensitive domain of medical imaging. As the adoption of AI in healthcare increases, explainability becomes a key factor in gaining the trust of clinicians and patients and ensuring the ethical use of AI in critical health decisions.

The goal of this Special Issue is to bring together recent advances and cutting-edge research in the use of both deep learning and XAI in medical image analysis. The issue also aims to provide a comprehensive overview of the current state-of-the-art and to highlight the challenges, opportunities, and future directions of this rapidly evolving field. The addition of explainability considerations will not only address technical aspects but also delve into the implications for clinical workflows, regulatory standards, and patient safety.

The scope of the Special Issue is interdisciplinary, bringing together experts from various fields such as computer science, engineering, medicine, biology, and ethics. The Issue is designed to be a useful resource for researchers, clinicians, and practitioners in the field of medical imaging, and to provide them with valuable insights into the latest developments, trends, and the growing need for interpretability in AI-driven models.

The focus of the Special Issue is on the practical applications, novel approaches, and explainability of deep learning in medical image analysis, including but not limited to:

  • Novel applications of deep learning (DL) in medical image processing and analysis;
  • DL approaches for medical image segmentation and classification (X-rays, CT, MRI, PET, ultrasound);
  • DL approaches for medical image registration, super-resolution, and resampling;
  • Un/semi/weakly supervised learning for medical image processing and analysis;
  • Domain adaptation, transfer learning, and adversarial learning in medical imaging with DL;
  • Multi-modal medical imaging data fusion and integration with DL;
  • Joint latent space learning with DL for medical imaging and non-imaging data integration;
  • Spatiotemporal medical imaging and image analysis using DL;
  • Explainable AI techniques applied to medical image analysis to enhance interpretability and transparency;
  • Model explainability and trustworthiness in AI-driven medical applications;
  • Regulatory considerations and challenges in the deployment of XAI in healthcare;
  • Novel datasets, challenges, and benchmarks for application and evaluation of DL; annotation-efficient approaches to DL;
  • Comprehensive surveys and reviews on medical image processing, analysis, and explainability.

This Special Issue provides a valuable supplement to the existing literature in the field by bringing together a wide range of perspectives on the use of deep learning and XAI in medical image analysis. The Issue is an excellent resource for researchers, clinicians, and practitioners interested in exploring the potential of deep learning and explainable AI for medical image analysis.

We invite submissions from researchers and practitioners in these exciting and rapidly growing fields as we work towards revolutionizing medical image analysis and ensuring that deep learning technologies are both powerful and understandable in their application to healthcare.

Dr. Marija Habijan
Dr. Irena Galić
Dr. Daniel Vasić
Dr. Mirela Kundid Vasić
Guest Editors

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Keywords

  • medical image analysis
  • image processing
  • image classification
  • image segmentation
  • image registration
  • image reconstruction
  • X-rays
  • CT scans
  • MRI
  • PET
  • ultrasound
  • computer-aided diagnosis
  • computer-aided treatment planning
  • artificial intelligence
  • deep learning
  • machine learning
  • neural networks
  • explainable artificial intelligence (XAI)
  • model interpretability
  • transparency in AI

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Related Special Issue

Published Papers (4 papers)

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Research

21 pages, 3031 KiB  
Article
Metric-Based Meta-Learning Approach for Few-Shot Classification of Brain Tumors Using Magnetic Resonance Images
by Sahar Gull and Juntae Kim
Electronics 2025, 14(9), 1863; https://doi.org/10.3390/electronics14091863 - 2 May 2025
Viewed by 419
Abstract
Brain tumor prediction from magnetic resonance images is an important problem, but it is difficult due to the complexity of brain structure and variability in tumor appearance. There have been various ML and DL-based approaches, but the limitations of current models are a [...] Read more.
Brain tumor prediction from magnetic resonance images is an important problem, but it is difficult due to the complexity of brain structure and variability in tumor appearance. There have been various ML and DL-based approaches, but the limitations of current models are a lack of adaptability to new tasks and a need for extensive training on large datasets. To address these issues, a novel meta-learning approach has been proposed, enabling rapid adaptation with limited data. This paper presents a method that integrates a vision transformer with a metric-based model, and few-shot learning to enhance classification performance. The proposed method begins with preprocessing MRI images, followed by feature extraction using a vision transformer. A metric-based Siamese network enhances the model’s learning, enabling quick adaptation to unseen data and improving robustness. Furthermore, applying a few-shot learning strategy enhances performance when there is limited training data. A comparison of the model’s performance with other developed models reveals that it consistently performs better. It has also been compared with previously proposed approaches with the same datasets using evaluation metrics including accuracy, precision, specificity, recall, and F1-score. The results demonstrate the efficacy of our methodology for brain tumor classification, which has significant implications for enhancing diagnostic accuracy and patient outcomes. Full article
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18 pages, 1897 KiB  
Article
Multi-Path Convolutional Architecture with Channel-Wise Attention for Multiclass Brain Tumor Detection in Magnetic Resonance Imaging Scans
by Muneeb A. Khan, Tsagaanchuluun Sugir, Byambaa Dorj, Ganchimeg Uuganchimeg, Seonuck Paek, Khurelbaatar Zagarzusem and Heemin Park
Electronics 2025, 14(9), 1741; https://doi.org/10.3390/electronics14091741 - 24 Apr 2025
Viewed by 296
Abstract
Accurately detecting and classifying brain tumors in magnetic resonance imaging (MRI) scans poses formidable challenges, stemming from the heterogeneous presentation of tumors and the need for reliable, real-time diagnostic outputs. In this paper, we propose a novel multi-path convolutional architecture enhanced with channel-wise [...] Read more.
Accurately detecting and classifying brain tumors in magnetic resonance imaging (MRI) scans poses formidable challenges, stemming from the heterogeneous presentation of tumors and the need for reliable, real-time diagnostic outputs. In this paper, we propose a novel multi-path convolutional architecture enhanced with channel-wise attention mechanisms, evaluated on a comprehensive four-class brain tumor dataset. Specifically: (i) we design a parallel feature extraction strategy that captures nuanced tumor morphologies, while channel-wise attention refines salient characteristics; (ii) we employ systematic data augmentation, yielding a balanced dataset of 6380 MRI scans to bolster model generalization; (iii) we compare the proposed architecture against state-of-the-art models, demonstrating superior diagnostic performance with 97.52% accuracy, 97.63% precision, 97.18% recall, 98.32% specificity, and an F1-score of 97.36%; and (iv) we report an inference speed of 5.13 ms per scan, alongside a higher memory footprint of approximately 26 GB, underscoring both the feasibility for real-time clinical application and the importance of resource considerations. These findings collectively highlight the proposed framework’s potential for improving automated brain tumor detection workflows and prompt further optimization for broader clinical deployment. Full article
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25 pages, 9176 KiB  
Article
Dynamic Ensemble Learning with Gradient-Weighted Class Activation Mapping for Enhanced Gastrointestinal Disease Classification
by Chih Mao Tsai and Jiann-Der Lee
Electronics 2025, 14(2), 305; https://doi.org/10.3390/electronics14020305 - 14 Jan 2025
Cited by 1 | Viewed by 900
Abstract
Gastrointestinal (GI) disease classification through endoscopic images is a critical yet challenging task, due to inter-class variability and subtle feature overlaps. This study introduces a novel ensemble learning framework that combines case-specific dynamic weighting with Gradient-weighted Class Activation Mapping (Grad-CAM) to enhance both [...] Read more.
Gastrointestinal (GI) disease classification through endoscopic images is a critical yet challenging task, due to inter-class variability and subtle feature overlaps. This study introduces a novel ensemble learning framework that combines case-specific dynamic weighting with Gradient-weighted Class Activation Mapping (Grad-CAM) to enhance both accuracy and interpretability. Three state-of-the-art convolutional neural networks (DenseNet201, InceptionV3, and VGG19) were fine-tuned on the Kvasir v2 dataset and integrated using optimized weights (0.4, 0.4, and 0.2, respectively). The ensemble achieved an accuracy of 0.91, outperforming individual models, particularly in complex classes such as Esophagitis and Normal-Z-Line. Grad-CAM visualizations confirmed the ensemble’s focus on clinically relevant features, highlighting its potential to improve diagnostic interpretability. While the dynamic ensemble approach significantly enhanced classification performance, further refinement is needed to address subtle and ambiguous cases. These results underscore the promise of dynamic ensemble learning as an explainable and clinically applicable tool in medical imaging. Full article
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30 pages, 11462 KiB  
Article
Revealing Occult Malignancies in Mammograms Through GAN-Driven Breast Density Transformation
by Dionysios Anyfantis, Athanasios Koutras, George Apostolopoulos and Ioanna Christoyianni
Electronics 2024, 13(23), 4826; https://doi.org/10.3390/electronics13234826 - 6 Dec 2024
Viewed by 909
Abstract
Breast cancer remains one of the primary causes of cancer-related deaths among women globally. Early detection via mammography is essential for improving prognosis and survival rates. However, mammogram diagnostic accuracy is severely hindered by dense breast tissue, which can obstruct potential malignancies, complicating [...] Read more.
Breast cancer remains one of the primary causes of cancer-related deaths among women globally. Early detection via mammography is essential for improving prognosis and survival rates. However, mammogram diagnostic accuracy is severely hindered by dense breast tissue, which can obstruct potential malignancies, complicating early detection. To tackle this pressing issue, this study introduces an innovative approach that leverages Generative Adversarial Networks (GANs), specifically CycleGAN and GANHopper, to transform breast density in mammograms. The aim is to diminish the masking effect of dense tissue, thus enhancing the visibility of underlying malignancies. The method uses unsupervised image-to-image translation to gradually alter breast density (from high (ACR-D) to low (ACR-A)) in mammographic images, detecting obscured lesions while preserving original diagnostic features. We applied this approach to multiple mammographic datasets, demonstrating its effectiveness in diverse contexts. Experimental results exhibit substantial improvements in detecting potential malignancies concealed by dense breast tissue. The method significantly improved precision, recall, and F1-score metrics across all datasets, revealing previously obscured malignancies and image quality assessments confirmed the diagnostic relevance of transformed images. The study introduces a novel mammogram analysis method using advanced machine-learning techniques, enhancing diagnostic accuracy in dense breasts and potentially improving early breast cancer detection and patient outcomes. Full article
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