Molecular Diagnosis and Treatment of Neurodegenerative Diseases
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 367
Special Issue Editors
Interests: molecular pathways of neurodegeneration; neuroprotection; neurodegeneration; nervous system cancers
Special Issue Information
Dear Colleagues,
Neurodegeneration is the progressive loss of neuronal structure and function resulting in the death of neurons and has a very complex and multifactorial progression. Therefore, the term “neurodegenerative disease” corresponds to a variety of conditions that finally lead to neuronal disruption and death. Among the known mechanisms of neurodegenerative diseases are misfolding/accumulation of proteins, disruption of intracellular calcium balance, mitochondrial dysfunction, formation of oxidative stress and DNA damage. Since neurodegenerative diseases have multifactorial etiologies, there are numerous obstacles impeding their diagnosis and treatment, and causing them to be categorized as incurable diseases. One major obstacle is the poor characterization of disease pathophysiology. For instance, some of the diseases have a genetic basis, while others do not have any known genetic defects. In addition, there are pathogenic interactions between various intracellular processes and molecules contributing to disease progression, making it more sophisticated. It is incontrovertible that it is difficult to develop diagnostic and treatment methods for a disease group whose molecular basis is not well understood. However, despite all the difficulties, the search for biomarkers to develop more effective diagnostic approaches and, accordingly, the efforts to develop new treatment regimens continue actively.
Considering the multifaceted and challenging nature of neurodegenerative diseases, this Special Issue aims at discussing current molecular approaches used in the diagnosis and/or treatment of different neurodegenerative diseases, as well as emerging and promising new molecular diagnostic and treatment strategies with their advantages and disadvantages.
Dr. Ayşegül Yildiz
Dr. Gizem Donmez Yalcin
Guest Editors
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Keywords
- neurodegeneration
- neuroinflammation
- neurodegenerative diseases
- molecular diagnosis
- diagnostics
- biomarkers for neurodegeneration
- neuroprotection
- preventive treatment
- ALS
- Alzheimer’s disease
- Parkinson’s disease
- Huntington disease
- Lewy body dementia
- Friedreich’s ataxia
- molecular neurobiology
- protein misfolding
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