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Multidisciplinary Diagnostic Approaches to Infectious Pathologies in Surgical Specialties

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Diagnostic Microbiology and Infectious Disease".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 2371

Special Issue Editors


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Guest Editor
1. Department of Microbiology, “Cantacuzino” Institute, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
2. Emergency Hospital-Surgery Department, Elias University, 020021 Bucharest, Romania
Interests: general surgery; abdominal surgery; emergency surgery; endocrine surgery

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Guest Editor
Department of Surgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: minimal invasive surgery; endocrine surgery; breast cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Infectious complications in surgical specialties remain a formidable challenge, driving morbidity, mortality, and healthcare costs while being further exacerbated by antimicrobial resistance.  The effective management of these infections demands precision diagnostics, timely intervention, and—critically—a collaborative framework that transcends traditional silos in surgical practice.

This Special Issue of Diagnostics highlights the pivotal role of multidisciplinary synergy in diagnosing and managing surgical infectious pathologies.  We invite contributions that explore advanced diagnostic modalities (e.g., molecular imaging, rapid microbiological assays, and AI-driven diagnostics), innovative therapeutic strategies, and the integrative decision-making processes essential for optimal outcomes.  Key themes include the following:

  • Diagnostic advancements: Novel technologies and protocols for early, accurate detection of surgical infections.
  • Interdisciplinary collaboration: Roles of surgeons, infectious disease specialists, microbiologists, radiologists, and pathologists in joint diagnostics and treatment planning.
  • Antimicrobial stewardship: Diagnostic tools to guide targeted therapy amid rising resistance.
  • Case-based insights: Practical applications of multidisciplinary approaches in diverse surgical settings.

By curating high-quality research and reviews, this Special Issue aims at bridging gaps between theory and practice, offering clinicians, researchers, and policymakers actionable insights to enhance patient safety and global surgical infection management.  We welcome original studies, meta-analyses, and forward-looking perspectives that underscore the transformative potential of diagnostics in multidisciplinary care.

Dr. Elena Adelina Toma
Dr. Octavian Enciu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • surgical infections
  • diagnostic advancements
  • antimicrobial resistance
  • molecular diagnostics
  • radiological imaging
  • microbiological assays
  • AI-driven diagnostics

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Published Papers (1 paper)

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Review

15 pages, 300 KB  
Review
The Evolving Microbiology and Antimicrobial Resistance in Peritonitis of Biliary Origin: An Evidence-Based Update of the Tokyo Guidelines (TG18) for Clinicians
by Elena-Adelina Toma, Octavian Enciu, Gabriela Loredana Popa, Valentin Calu, Dumitru Cătălin Pîrîianu, Andrei Ludovic Poroșnicu and Mircea Ioan Popa
Diagnostics 2025, 15(24), 3095; https://doi.org/10.3390/diagnostics15243095 - 5 Dec 2025
Viewed by 1481
Abstract
Background: Biliary peritonitis is a severe intra-abdominal emergency with high mortality. Effective management requires source control and appropriate antimicrobial therapy. Methods: This review synthesizes recent literature (2016–2025), as well as established guidelines recommendations on the evolving microbiology and antimicrobial resistance patterns [...] Read more.
Background: Biliary peritonitis is a severe intra-abdominal emergency with high mortality. Effective management requires source control and appropriate antimicrobial therapy. Methods: This review synthesizes recent literature (2016–2025), as well as established guidelines recommendations on the evolving microbiology and antimicrobial resistance patterns in biliary tract infections, as data on biliary peritonitis is scarce and relatively heterogeneous. Results: The microbiological landscape is stratified by patient history. Community-acquired infections are typically caused by Escherichia coli, Klebsiella pneumoniae, and Enterococcus spp. In contrast, healthcare-associated infections show a shift, with highly resistant pathogens such as Pseudomonas aeruginosa, and a tendency towards polymicrobial infections. The rise of multidrug-resistant (MDR) organisms, including extended-spectrum β-lactamase (ESBL)-producing Enterobacterales, Carbapenem-Resistant Enterobacterales (CRE), and Vancomycin-Resistant Enterococci (VRE), is a critical challenge limiting therapeutic options. Resistance patterns vary geographically, necessitating the use of local data. Conclusions: This review argues for a paradigm shift from severity-based guidelines to a dual-axis model incorporating resistance risk factors (prior healthcare exposure, previous biliary interventions, a history of MDR infections). We propose a risk-stratified approach to empiric antibiotic selection, emphasizing microbiological diagnostics for therapy de-escalation. Future research should focus on prospective studies, novel antibiotics, and rapid diagnostics. Full article
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