Advances in Diabetic Wound Healing: From Mechanisms to Therapies

Dear Colleagues,

The treatment of chronic wounds in diabetes represents a huge clinical challenge, which is ever-increasing. Investigating mechanisms of the development of these wounds, and determining novel therapeutic targets, alongside enhancing current treatments, is key to tackling this huge burden on people with diabetes and their care teams. The modular and cellular mechanism occurring during the initiation and progression of wounds has been advanced by recent research; however, the impairment of healing of chronic wounds is still only partially understood.

Although we understand the effects of diabetic ulcer and diabetic foot disease, and that once a person with diabetes develops one ulcer, they will likely go on to develop more, which goes hand in hand with the length of time that they have been diagnosed with diabetes, treatments are often similar as they have been for many years and progression of treatment options is essential.

To advance the understanding of the pathology and treatment of chronic wounds, particularly diabetic foot ulcers, Diabetology will publish a Special Issue focused on wound healing and tissue repair in diabetes. Potential topics include, but are not limited to, the following:

• Mechanistic effects of hyperglycaemia on cutaneous cells: fibroblasts, endothelial cells, and keratinocytes;
• Links between glucose toxicity and senescence of fibroblasts and keratinocytes;
• Cell signalling and intracellular networks, apoptosis and proliferation in chronic wounds;
• Animal models of chronic wounds;
• Molecular markers of wound chronicity or predictors for wound healing;
• Roles of biofilms in wound failure;
• Clinical management of chronic infections;
• Novel approaches to treatment of chronic wounds;
• Pharmacological interventions to modulate inflammation and proteolysis in diabetic chronic wounds;
• Clinical trials investigating novel treatments or regimens;
• Advances in wound dressings to improve healing.

We welcome the submission of Original Research Articles, Reviews, and Systematic Reviews that will advance our understanding and stimulate discussion in this vital field.

Dr. Catherine S. Wright
Prof. Dr. Gordon Ramage
Dr. Steven Patterson
Guest Editors

Manuscript Submission Information

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