Advances in Periodontal and Implant Therapies: Regeneration, Biomaterials, and Clinical Innovations

A special issue of Dentistry Journal (ISSN 2304-6767). This special issue belongs to the section "Oral Hygiene, Periodontology and Peri-implant Diseases".

Deadline for manuscript submissions: closed (25 March 2026) | Viewed by 1407

Special Issue Editor


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Guest Editor
Department of Oral and Maxillofacial Surgery and Oral Medicine, Malmö University, 211 19 Malmö, Sweden
Interests: clinical dentistry; restorative dentistry; esthetic dentistry; fixed prosthodontics; implant dentistry; oral surgery; periodontology; dental implantology; oral implantology

Special Issue Information

Dear Colleagues,

The field of periodontal and implant therapy is undergoing profound changes, driven by the integration of cutting-edge technologies, biomaterials, and interdisciplinary clinical strategies. This Special Issue, “Advances in Periodontal and Implant Therapies: Regeneration, Biomaterials, and Clinical Innovations”, aims to bring together original research and critical reviews addressing the current challenges and future directions in these evolving areas.

Contemporary implantology and periodontal therapy go far beyond surgical procedures — they now represent a comprehensive biological and technological continuum, integrating precision diagnostics, minimally invasive protocols, and long-term maintenance strategies.

We invite submissions exploring, but not limited to, the following key areas:

  1. Implant and Regenerative Innovation
    Research into advanced implant designs, surface modifications, macro geometries, and novel biomaterials to improve osseointegration, facilitate immediate loading, and reduce peri-implant disease risk. Studies on regenerative techniques, including GBR, sinus lifts, soft tissue augmentation, and the application of next-generation biomaterials (e.g., bioactive scaffolds, growth factors), are highly encouraged.
  2. Periodontal and Peri-Implant Disease Management
    Investigations focusing on the diagnosis, prevention, and treatment of periodontitis and peri-implant diseases. This includes antimicrobial strategies, host-modulating therapies, laser-assisted protocols, and risk factor control (e.g., smoking, diabetes, occlusal trauma). We welcome studies that explore the biological pathways involved in tissue inflammation and bone loss.
  3. Technological Integration in Diagnosis and Treatment Planning
    Contributions related to digital workflows, including intraoral scanning, dynamic and static guided surgery, 3D diagnostics, AI-driven risk assessment, and virtual planning for both periodontal and implant cases.
  4. Oral Hygiene Protocols and Long-Term Maintenance
    Emphasis on personalized hygiene protocols, patient education, and long-term supportive therapy. Studies evaluating the impact of professional prophylaxis systems (e.g., airflow, ultrasonic debridement), digital monitoring tools, and the role of dental hygienists in improving clinical outcomes are welcome.

We encourage submissions that integrate biological, procedural, and technological perspectives and that highlight how innovation can enhance patient care, the longevity of treatment, and interdisciplinary collaboration.

Dr. Marco Toia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • implant design innovations
  • periodontal regeneration
  • peri-implant disease management
  • digital workflow in dentistry
  • bone and soft tissue augmentation
  • guided implant surgery
  • oral hygiene protocols
  • biomaterials in implant dentistry
  • supportive periodontal therapy
  • minimally invasive implantology

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Published Papers (2 papers)

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Research

14 pages, 5665 KB  
Article
Transcrestal Sinus Elevation with Implant Placement Using Autogenous Bone Supporting Multilayer Crosslinked Collagen Xenograft Scaffolding: A Case Series
by David Barack, Chander S. Gupta, Luigi Canullo and Marco Toia
Dent. J. 2026, 14(1), 64; https://doi.org/10.3390/dj14010064 - 19 Jan 2026
Viewed by 449
Abstract
Background/Objectives: Limited residual bone height in the atrophic posterior maxilla complicates implant placement. Transcrestal sinus elevation can be used to correct bone shrinkage after sinus pneumatization or crestal bone loss. This study evaluated a minimally invasive, one-stage transcrestal sinus lift using a [...] Read more.
Background/Objectives: Limited residual bone height in the atrophic posterior maxilla complicates implant placement. Transcrestal sinus elevation can be used to correct bone shrinkage after sinus pneumatization or crestal bone loss. This study evaluated a minimally invasive, one-stage transcrestal sinus lift using a double-layer crosslinked collagen scaffold (MCCS) with autogenous bone from the implant osteotomy site in patients with RBH ≤ 6 mm. Methods: In this prospective series, 11 patients (48–64 years, mean RBH 4.75 mm, SD 0.95 mm) underwent one-stage transcrestal sinus floor elevation with simultaneous implants. After osteotomy, autogenous bone chips collected during drilling were compacted into the site, and two layers of MCCS were placed under the elevated Schneiderian membrane. Buccal and palatal bone heights were measured on CBCT before and after surgery to assess vertical bone gain (ΔRBH). Results: All implants achieved stable osseointegration. Mean ΔRBH was approximately 3.1 ± 0.9 mm (combined buccal–palatal). No postoperative complications occurred. Two small Schneiderian membrane perforations were sealed intraoperatively by MCCS placement, with uneventful healing. Follow-up imaging showed maintenance of the augmented bone around the implants. Conclusions: This double-layer MCCS plus autogenous bone approach is a safe, effective, and minimally invasive transcrestal sinus lift for atrophic maxillae. It yielded crestal bone gains even with minimal initial RBH, leveraging the palatal sinus wall’s osteogenic potential and the implant’s tent-pole effect. The MCCS scaffold maintained space for bone formation and enabled immediate sealing of any membrane perforations. This one-stage protocol is viable for implant placement in low-RBH sites. Full article
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10 pages, 922 KB  
Article
Impact of Bone Grafts Containing Metformin on Implant Surface Hydrophilicity: An In Vitro Study
by Rahul Minesh Shah, Nina Anderson, Rafael Delgado-Ruiz and Georgios Romanos
Dent. J. 2025, 13(12), 611; https://doi.org/10.3390/dj13120611 - 18 Dec 2025
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Abstract
Background/Objectives: The effect of metformin combined with bone grafting materials and its effect on the hydrophilicity of different implant surfaces has not been investigated. Investigation of the use of metformin as a therapeutic for implant surface treatment may be useful in improving [...] Read more.
Background/Objectives: The effect of metformin combined with bone grafting materials and its effect on the hydrophilicity of different implant surfaces has not been investigated. Investigation of the use of metformin as a therapeutic for implant surface treatment may be useful in improving overall implant longevity and success. Methods: Herein, a 1.5% metformin solution was created with crystalline metformin and distilled water. Titanium alloy (machined surface), titanium with sandblasted, large-grit acid-etched surface (Ti-SLA), and zirconia (SDS) surfaces were treated with five different solutions: 0.9% sodium chloride (Group A), bovine cancellous bone graft (Bio-Oss®)/0.9% sodium chloride solution (Group B), Bio-Oss® bone graft with metformin/0.9% sodium chloride solution (Group C), algae-based bone graft (AlgOss®)/0.9% sodium chloride solution (Group D), and AlgOss® bone graft with metformin/0.9% sodium chloride solution (Group E). Hydrophilicity tests utilizing droplet angle measurements (n = 20 droplets/disk) of each of the solutions were carried out (total N = 600 contact angle measurements). Statistical comparison between treatment groups for each implant surface using ANOVA and Bonferroni correction at p < 0.05 was performed. Results: Analyses revealed a statistically significant improvement in hydrophilicity for group C compared to group B (p < 0.05) in Ti-alloy, but a significant decrease in hydrophilicity for group E compared to group D in Ti-SLA. Zirconia surfaces displayed a decrease in hydrophilicity for all groups compared to group A. Conclusions: Thus, there were varying effects of combined metformin and bone graft on implants. Full article
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